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Fusion gene ID: 36863 |
FusionGeneSummary for SYCP2_BCAS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SYCP2_BCAS1 | Fusion gene ID: 36863 | Hgene | Tgene | Gene symbol | SYCP2 | BCAS1 | Gene ID | 10388 | 8537 |
| Gene name | synaptonemal complex protein 2 | breast carcinoma amplified sequence 1 | |
| Synonyms | SCP-2|SCP2 | AIBC1|NABC1 | |
| Cytomap | 20q13.33 | 20q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | synaptonemal complex protein 2synaptonemal complex lateral element protein | breast carcinoma-amplified sequence 1amplified and overexpressed in breast cancernovel amplified in breast cancer 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9BX26 | O75363 | |
| Ensembl transtripts involved in fusion gene | ENST00000357552, ENST00000371001, ENST00000476314, | ENST00000371440, ENST00000371435, ENST00000395961, ENST00000434986, ENST00000411563, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 11 X 7 X 8=616 |
| # samples | 2 | 11 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(11/616*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SYCP2 [Title/Abstract] AND BCAS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AN-A0FY-01A | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000357552 | ENST00000371440 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| 5CDS-intron | ENST00000357552 | ENST00000371435 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| 5CDS-intron | ENST00000357552 | ENST00000395961 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| 5CDS-intron | ENST00000357552 | ENST00000434986 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| 5CDS-intron | ENST00000357552 | ENST00000411563 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| 5CDS-intron | ENST00000371001 | ENST00000371440 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| 5CDS-intron | ENST00000371001 | ENST00000371435 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| 5CDS-intron | ENST00000371001 | ENST00000395961 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| 5CDS-intron | ENST00000371001 | ENST00000434986 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| 5CDS-intron | ENST00000371001 | ENST00000411563 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| intron-intron | ENST00000476314 | ENST00000371440 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| intron-intron | ENST00000476314 | ENST00000371435 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| intron-intron | ENST00000476314 | ENST00000395961 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| intron-intron | ENST00000476314 | ENST00000434986 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
| intron-intron | ENST00000476314 | ENST00000411563 | SYCP2 | chr20 | 58440443 | - | BCAS1 | chr20 | 52574036 | - |
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FusionProtFeatures for SYCP2_BCAS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SYCP2 | BCAS1 |