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Fusion gene ID: 36827 |
FusionGeneSummary for SUZ12_STAP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SUZ12_STAP2 | Fusion gene ID: 36827 | Hgene | Tgene | Gene symbol | SUZ12 | STAP2 | Gene ID | 23512 | 55620 |
| Gene name | SUZ12, polycomb repressive complex 2 subunit | signal transducing adaptor family member 2 | |
| Synonyms | CHET9|JJAZ1 | BKS | |
| Cytomap | 17q11.2 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | polycomb protein SUZ12chET 9 proteinchromatin precipitated E2F target 9 proteinjoined to JAZF1 proteinsuppressor of zeste 12 protein homolog | signal-transducing adaptor protein 2BRK substratebreast tumor kinase substratebrk kinase substrate | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q15022 | Q9UGK3 | |
| Ensembl transtripts involved in fusion gene | ENST00000322652, ENST00000580398, | ENST00000600324, ENST00000594605, ENST00000597593, | |
| Fusion gene scores | * DoF score | 7 X 8 X 8=448 | 6 X 4 X 5=120 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/448*10)=-2.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SUZ12 [Title/Abstract] AND STAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-BC-A10Z-01A | SUZ12 | chr17 | 30310123 | + | STAP2 | chr19 | 4325542 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000322652 | ENST00000600324 | SUZ12 | chr17 | 30310123 | + | STAP2 | chr19 | 4325542 | - |
| Frame-shift | ENST00000322652 | ENST00000594605 | SUZ12 | chr17 | 30310123 | + | STAP2 | chr19 | 4325542 | - |
| 5CDS-5UTR | ENST00000322652 | ENST00000597593 | SUZ12 | chr17 | 30310123 | + | STAP2 | chr19 | 4325542 | - |
| Frame-shift | ENST00000580398 | ENST00000600324 | SUZ12 | chr17 | 30310123 | + | STAP2 | chr19 | 4325542 | - |
| Frame-shift | ENST00000580398 | ENST00000594605 | SUZ12 | chr17 | 30310123 | + | STAP2 | chr19 | 4325542 | - |
| 5CDS-5UTR | ENST00000580398 | ENST00000597593 | SUZ12 | chr17 | 30310123 | + | STAP2 | chr19 | 4325542 | - |
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FusionProtFeatures for SUZ12_STAP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SUZ12 | STAP2 |