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Fusion gene ID: 36793 |
FusionGeneSummary for SUPT6H_TJP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SUPT6H_TJP1 | Fusion gene ID: 36793 | Hgene | Tgene | Gene symbol | SUPT6H | TJP1 | Gene ID | 6830 | 7082 |
| Gene name | SPT6 homolog, histone chaperone | tight junction protein 1 | |
| Synonyms | SPT6|SPT6H|emb-5 | ZO-1 | |
| Cytomap | 17q11.2 | 15q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription elongation factor SPT6histone chaperone suppressor of Ty6suppressor of Ty 6 homologtat-CT2 proteintat-cotransactivator 2 protein | tight junction protein ZO-1zona occludens 1zonula occludens 1 protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q7KZ85 | Q07157 | |
| Ensembl transtripts involved in fusion gene | ENST00000314616, ENST00000347486, | ENST00000346128, ENST00000400011, ENST00000356107, ENST00000545208, ENST00000495972, | |
| Fusion gene scores | * DoF score | 9 X 10 X 4=360 | 5 X 6 X 3=90 |
| # samples | 10 | 6 | |
| ** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SUPT6H [Title/Abstract] AND TJP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A250-01A | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000314616 | ENST00000346128 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
| 5CDS-intron | ENST00000314616 | ENST00000400011 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
| 5CDS-intron | ENST00000314616 | ENST00000356107 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
| 5CDS-intron | ENST00000314616 | ENST00000545208 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
| 5CDS-intron | ENST00000314616 | ENST00000495972 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
| 5CDS-intron | ENST00000347486 | ENST00000346128 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
| 5CDS-intron | ENST00000347486 | ENST00000400011 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
| 5CDS-intron | ENST00000347486 | ENST00000356107 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
| 5CDS-intron | ENST00000347486 | ENST00000545208 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
| 5CDS-intron | ENST00000347486 | ENST00000495972 | SUPT6H | chr17 | 27013807 | + | TJP1 | chr15 | 30248567 | - |
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FusionProtFeatures for SUPT6H_TJP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SUPT6H | TJP1 |