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Fusion gene ID: 36777

FusionGeneSummary for SUPT5H_CATSPERG

Fusion gene summary

Fusion gene information	Fusion gene name: SUPT5H_CATSPERG
	Fusion gene ID: 36777
		Hgene	Tgene
	Gene symbol	SUPT5H	CATSPERG
	Gene ID	6829	57828
	Gene name	SPT5 homolog, DSIF elongation factor subunit	cation channel sperm associated auxiliary subunit gamma
	Synonyms	SPT5\|SPT5H\|Tat-CT1	C19orf15
	Cytomap	19q13.2	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	transcription elongation factor SPT5DRB sensitivity-inducing factor 160 kDa subunitDRB sensitivity-inducing factor large subunitDSIF large subunitDSIF p160Tat-cotransactivator 1 proteinhSPT5suppressor of Ty 5 homolog	cation channel sperm-associated protein subunit gammacatsper channel auxiliary subunit gamma
	Modification date	20180523	20180522
	UniProtAcc	O00267	Q6ZRH7
	Ensembl transtripts involved in fusion gene	ENST00000599117, ENST00000432763, ENST00000402194, ENST00000359191, ENST00000598725,	ENST00000409235, ENST00000410018, ENST00000215069, ENST00000467739,
Fusion gene scores	* DoF score	13 X 9 X 8=936	5 X 4 X 4=80
	# samples	12	4
	** MAII score	log2(12/936*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SUPT5H [Title/Abstract] AND CATSPERG [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SUPT5H	GO:0000122	negative regulation of transcription by RNA polymerase II	9450929
Hgene	SUPT5H	GO:0006368	transcription elongation from RNA polymerase II promoter	9450929
Hgene	SUPT5H	GO:0032785	negative regulation of DNA-templated transcription, elongation	9450929
Hgene	SUPT5H	GO:0032786	positive regulation of DNA-templated transcription, elongation	9450929
Hgene	SUPT5H	GO:0045944	positive regulation of transcription by RNA polymerase II	9450929

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	OV	TCGA-29-1766-01A	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000599117	ENST00000409235	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
In-frame	ENST00000599117	ENST00000410018	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
5CDS-3UTR	ENST00000599117	ENST00000215069	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
5CDS-intron	ENST00000599117	ENST00000467739	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
In-frame	ENST00000432763	ENST00000409235	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
In-frame	ENST00000432763	ENST00000410018	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
5CDS-3UTR	ENST00000432763	ENST00000215069	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
5CDS-intron	ENST00000432763	ENST00000467739	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
In-frame	ENST00000402194	ENST00000409235	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
In-frame	ENST00000402194	ENST00000410018	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
5CDS-3UTR	ENST00000402194	ENST00000215069	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
5CDS-intron	ENST00000402194	ENST00000467739	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
In-frame	ENST00000359191	ENST00000409235	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
In-frame	ENST00000359191	ENST00000410018	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
5CDS-3UTR	ENST00000359191	ENST00000215069	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
5CDS-intron	ENST00000359191	ENST00000467739	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
In-frame	ENST00000598725	ENST00000409235	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
In-frame	ENST00000598725	ENST00000410018	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
5CDS-3UTR	ENST00000598725	ENST00000215069	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+
5CDS-intron	ENST00000598725	ENST00000467739	SUPT5H	chr19	39936582	+	CATSPERG	chr19	38855583	+

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FusionProtFeatures for SUPT5H_CATSPERG

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SUPT5H O00267	CATSPERG Q6ZRH7

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Fusion gene ID: 36777

FusionGeneSummary for SUPT5H_CATSPERG

FusionProtFeatures for SUPT5H_CATSPERG