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Fusion gene ID: 3668

FusionGeneSummary for AXL_LTBP1

Fusion gene summary

Fusion gene information	Fusion gene name: AXL_LTBP1
	Fusion gene ID: 3668
		Hgene	Tgene
	Gene symbol	AXL	LTBP1
	Gene ID	558	4052
	Gene name	AXL receptor tyrosine kinase	latent transforming growth factor beta binding protein 1
	Synonyms	ARK\|JTK11\|Tyro7\|UFO	-
	Cytomap	19q13.2	2p22.3
	Type of gene	protein-coding	protein-coding
	Description	tyrosine-protein kinase receptor UFOAXL oncogeneAXL transforming sequence/gene	latent-transforming growth factor beta-binding protein 1LTBP-1TGF-beta1-BP-1transforming growth factor beta-1-binding protein 1
	Modification date	20180527	20180522
	UniProtAcc	P30530	Q14766
	Ensembl transtripts involved in fusion gene	ENST00000301178, ENST00000359092, ENST00000594880, ENST00000593513,	ENST00000404816, ENST00000354476, ENST00000390003, ENST00000418533, ENST00000402934, ENST00000404525, ENST00000407925, ENST00000272273, ENST00000498013,
Fusion gene scores	* DoF score	7 X 7 X 4=196	6 X 6 X 4=144
	# samples	7	7
	** MAII score	log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AXL [Title/Abstract] AND LTBP1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AXL	GO:0001961	positive regulation of cytokine-mediated signaling pathway	18840707
Hgene	AXL	GO:0006909	phagocytosis	21501828
Hgene	AXL	GO:0032689	negative regulation of interferon-gamma production	18840707
Hgene	AXL	GO:0032825	positive regulation of natural killer cell differentiation	18840707
Hgene	AXL	GO:0035457	cellular response to interferon-alpha	19657094
Hgene	AXL	GO:0071222	cellular response to lipopolysaccharide	19657094
Hgene	AXL	GO:2000669	negative regulation of dendritic cell apoptotic process	19657094

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			CR740035	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3UTR	ENST00000301178	ENST00000404816	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
3UTR-3UTR	ENST00000301178	ENST00000354476	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
3UTR-3UTR	ENST00000301178	ENST00000390003	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
3UTR-3UTR	ENST00000301178	ENST00000418533	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
3UTR-3UTR	ENST00000301178	ENST00000402934	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
3UTR-3UTR	ENST00000301178	ENST00000404525	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
3UTR-3UTR	ENST00000301178	ENST00000407925	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
3UTR-intron	ENST00000301178	ENST00000272273	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
3UTR-intron	ENST00000301178	ENST00000498013	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000359092	ENST00000404816	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000359092	ENST00000354476	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000359092	ENST00000390003	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000359092	ENST00000418533	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000359092	ENST00000402934	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000359092	ENST00000404525	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000359092	ENST00000407925	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-intron	ENST00000359092	ENST00000272273	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-intron	ENST00000359092	ENST00000498013	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000594880	ENST00000404816	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000594880	ENST00000354476	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000594880	ENST00000390003	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000594880	ENST00000418533	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000594880	ENST00000402934	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000594880	ENST00000404525	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000594880	ENST00000407925	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-intron	ENST00000594880	ENST00000272273	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-intron	ENST00000594880	ENST00000498013	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000593513	ENST00000404816	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000593513	ENST00000354476	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000593513	ENST00000390003	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000593513	ENST00000418533	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000593513	ENST00000402934	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000593513	ENST00000404525	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-3UTR	ENST00000593513	ENST00000407925	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-intron	ENST00000593513	ENST00000272273	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+
intron-intron	ENST00000593513	ENST00000498013	AXL	chr19	41767546	+	LTBP1	chr2	33623778	+

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FusionProtFeatures for AXL_LTBP1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AXL P30530	LTBP1 Q14766

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Fusion gene ID: 3668

FusionGeneSummary for AXL_LTBP1

FusionProtFeatures for AXL_LTBP1