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Fusion gene ID: 36598 |
FusionGeneSummary for STRN3_METTL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STRN3_METTL3 | Fusion gene ID: 36598 | Hgene | Tgene | Gene symbol | STRN3 | METTL3 | Gene ID | 29966 | 56339 |
| Gene name | striatin 3 | methyltransferase like 3 | |
| Synonyms | PPP2R6B|S/G2NA|SG2NA | IME4|M6A|MT-A70|Spo8|hMETTL3 | |
| Cytomap | 14q12 | 14q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | striatin-3cell cycle S/G2 nuclear autoantigencell cycle autoantigen SG2NAnuclear autoantigenprotein phosphatase 2 regulatory subunit B'''betas/G2 antigenstriatin, calmodulin binding protein 3 | N6-adenosine-methyltransferase catalytic subunitN6-adenosine-methyltransferase 70 kDa subunitadoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferasemRNA (2'-O-methyladenosine-N(6)-)-methyltransferasemRNA m(6)A methyltransferasemethy | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13033 | Q86U44 | |
| Ensembl transtripts involved in fusion gene | ENST00000355683, ENST00000357479, ENST00000366206, | ENST00000298717, ENST00000538267, ENST00000545319, | |
| Fusion gene scores | * DoF score | 10 X 5 X 7=350 | 2 X 2 X 2=8 |
| # samples | 11 | 2 | |
| ** MAII score | log2(11/350*10)=-1.66985139830767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: STRN3 [Title/Abstract] AND METTL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | METTL3 | GO:0006974 | cellular response to DNA damage stimulus | 28297716 |
| Tgene | METTL3 | GO:0031053 | primary miRNA processing | 25799998 |
| Tgene | METTL3 | GO:0034644 | cellular response to UV | 28297716 |
| Tgene | METTL3 | GO:0080009 | mRNA methylation | 24316715|27281194|27373337|27627798|28297716 |
| Tgene | METTL3 | GO:1990744 | primary miRNA methylation | 25799998 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRC | TCGA-CJ-5677-01A | STRN3 | chr14 | 31404369 | - | METTL3 | chr14 | 21972024 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000355683 | ENST00000298717 | STRN3 | chr14 | 31404369 | - | METTL3 | chr14 | 21972024 | - |
| Frame-shift | ENST00000355683 | ENST00000538267 | STRN3 | chr14 | 31404369 | - | METTL3 | chr14 | 21972024 | - |
| 5CDS-intron | ENST00000355683 | ENST00000545319 | STRN3 | chr14 | 31404369 | - | METTL3 | chr14 | 21972024 | - |
| In-frame | ENST00000357479 | ENST00000298717 | STRN3 | chr14 | 31404369 | - | METTL3 | chr14 | 21972024 | - |
| Frame-shift | ENST00000357479 | ENST00000538267 | STRN3 | chr14 | 31404369 | - | METTL3 | chr14 | 21972024 | - |
| 5CDS-intron | ENST00000357479 | ENST00000545319 | STRN3 | chr14 | 31404369 | - | METTL3 | chr14 | 21972024 | - |
| intron-3CDS | ENST00000366206 | ENST00000298717 | STRN3 | chr14 | 31404369 | - | METTL3 | chr14 | 21972024 | - |
| intron-3CDS | ENST00000366206 | ENST00000538267 | STRN3 | chr14 | 31404369 | - | METTL3 | chr14 | 21972024 | - |
| intron-intron | ENST00000366206 | ENST00000545319 | STRN3 | chr14 | 31404369 | - | METTL3 | chr14 | 21972024 | - |
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FusionProtFeatures for STRN3_METTL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STRN3 | METTL3 |