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Fusion gene ID: 36595 |
FusionGeneSummary for STRN3_EGLN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STRN3_EGLN3 | Fusion gene ID: 36595 | Hgene | Tgene | Gene symbol | STRN3 | EGLN3 | Gene ID | 29966 | 112399 |
| Gene name | striatin 3 | egl-9 family hypoxia inducible factor 3 | |
| Synonyms | PPP2R6B|S/G2NA|SG2NA | HIFP4H3|HIFPH3|PHD3 | |
| Cytomap | 14q12 | 14q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | striatin-3cell cycle S/G2 nuclear autoantigencell cycle autoantigen SG2NAnuclear autoantigenprotein phosphatase 2 regulatory subunit B'''betas/G2 antigenstriatin, calmodulin binding protein 3 | egl nine homolog 3HIF-PH3HIF-prolyl hydroxylase 3HPH-1HPH-3egl nine-like protein 3 isoformhypoxia-inducible factor prolyl hydroxylase 3prolyl hydroxylase domain-containing protein 3 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q13033 | Q9H6Z9 | |
| Ensembl transtripts involved in fusion gene | ENST00000355683, ENST00000357479, ENST00000366206, | ENST00000250457, ENST00000553215, ENST00000547327, ENST00000557521, | |
| Fusion gene scores | * DoF score | 10 X 5 X 7=350 | 4 X 3 X 4=48 |
| # samples | 11 | 4 | |
| ** MAII score | log2(11/350*10)=-1.66985139830767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: STRN3 [Title/Abstract] AND EGLN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | EGLN3 | GO:0018126 | protein hydroxylation | 19584355 |
| Tgene | EGLN3 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 11598268 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-78-8660-01A | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000355683 | ENST00000250457 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| In-frame | ENST00000355683 | ENST00000553215 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| 5CDS-intron | ENST00000355683 | ENST00000547327 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| 5CDS-intron | ENST00000355683 | ENST00000557521 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| In-frame | ENST00000357479 | ENST00000250457 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| In-frame | ENST00000357479 | ENST00000553215 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| 5CDS-intron | ENST00000357479 | ENST00000547327 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| 5CDS-intron | ENST00000357479 | ENST00000557521 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| intron-3CDS | ENST00000366206 | ENST00000250457 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| intron-3CDS | ENST00000366206 | ENST00000553215 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| intron-intron | ENST00000366206 | ENST00000547327 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
| intron-intron | ENST00000366206 | ENST00000557521 | STRN3 | chr14 | 31495110 | - | EGLN3 | chr14 | 34400421 | - |
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FusionProtFeatures for STRN3_EGLN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STRN3 | EGLN3 |