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Fusion gene ID: 3659 |
FusionGeneSummary for AXIN1_TMEM207 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AXIN1_TMEM207 | Fusion gene ID: 3659 | Hgene | Tgene | Gene symbol | AXIN1 | TMEM207 | Gene ID | 8312 | 131920 |
| Gene name | axin 1 | transmembrane protein 207 | |
| Synonyms | AXIN|PPP1R49 | UNQ846 | |
| Cytomap | 16p13.3 | 3q28 | |
| Type of gene | protein-coding | protein-coding | |
| Description | axin-1axis inhibition protein 1axis inhibitor 1fused, mouse, homolog ofprotein phosphatase 1, regulatory subunit 49 | transmembrane protein 207SRSR846 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | O15169 | Q6UWW9 | |
| Ensembl transtripts involved in fusion gene | ENST00000262320, ENST00000354866, ENST00000481769, | ENST00000354905, | |
| Fusion gene scores | * DoF score | 11 X 4 X 8=352 | 4 X 2 X 2=16 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/352*10)=-1.55254102302878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: AXIN1 [Title/Abstract] AND TMEM207 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AXIN1 | GO:0001934 | positive regulation of protein phosphorylation | 9601641 |
| Hgene | AXIN1 | GO:0030178 | negative regulation of Wnt signaling pathway | 10644691 |
| Hgene | AXIN1 | GO:0032147 | activation of protein kinase activity | 9601641 |
| Hgene | AXIN1 | GO:0034622 | cellular protein-containing complex assembly | 16601693 |
| Hgene | AXIN1 | GO:0045732 | positive regulation of protein catabolic process | 9601641 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-77-8008-01A | AXIN1 | chr16 | 354304 | - | TMEM207 | chr3 | 190165616 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262320 | ENST00000354905 | AXIN1 | chr16 | 354304 | - | TMEM207 | chr3 | 190165616 | - |
| In-frame | ENST00000354866 | ENST00000354905 | AXIN1 | chr16 | 354304 | - | TMEM207 | chr3 | 190165616 | - |
| 5UTR-3CDS | ENST00000481769 | ENST00000354905 | AXIN1 | chr16 | 354304 | - | TMEM207 | chr3 | 190165616 | - |
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FusionProtFeatures for AXIN1_TMEM207 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AXIN1 | TMEM207 |