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Fusion gene ID: 36576 |
FusionGeneSummary for STRA6_NDUFAF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STRA6_NDUFAF1 | Fusion gene ID: 36576 | Hgene | Tgene | Gene symbol | STRA6 | NDUFAF1 | Gene ID | 64220 | 51103 |
| Gene name | stimulated by retinoic acid 6 | NADH:ubiquinone oxidoreductase complex assembly factor 1 | |
| Synonyms | MCOPCB8|MCOPS9|PP14296 | CGI-65|CGI65|CIA30 | |
| Cytomap | 15q24.1 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | receptor for retinol uptake STRA6retinol binding protein 4 receptorretinol-binding protein receptor STRA6stimulated by retinoic acid 6 homologstimulated by retinoic acid gene 6 homologstimulated by retinoic acid gene 6 protein homolog | complex I intermediate-associated protein 30, mitochondrialNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1NADH dehydrogenase (ubiquinone) complex I, assembly factor 1NADH-ubiquinone oxidoreductase 1 alpha subcomplex, assembly fact | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BX79 | Q9Y375 | |
| Ensembl transtripts involved in fusion gene | ENST00000395105, ENST00000423167, ENST00000323940, ENST00000449139, ENST00000416286, ENST00000574439, ENST00000535552, ENST00000563965, ENST00000574278, ENST00000432245, | ENST00000260361, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: STRA6 [Title/Abstract] AND NDUFAF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STRA6 | GO:0034633 | retinol transport | 21901792 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCS | TCGA-N5-A59F-01A | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000395105 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
| Frame-shift | ENST00000423167 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
| Frame-shift | ENST00000323940 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
| Frame-shift | ENST00000449139 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
| Frame-shift | ENST00000416286 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
| 5UTR-3CDS | ENST00000574439 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
| Frame-shift | ENST00000535552 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
| Frame-shift | ENST00000563965 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
| Frame-shift | ENST00000574278 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
| intron-3CDS | ENST00000432245 | ENST00000260361 | STRA6 | chr15 | 74476197 | - | NDUFAF1 | chr15 | 41679791 | - |
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FusionProtFeatures for STRA6_NDUFAF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STRA6 | NDUFAF1 |