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Fusion gene ID: 36555 |
FusionGeneSummary for STMN1_STARD7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STMN1_STARD7 | Fusion gene ID: 36555 | Hgene | Tgene | Gene symbol | STMN1 | STARD7 | Gene ID | 3925 | 56910 |
| Gene name | stathmin 1 | StAR related lipid transfer domain containing 7 | |
| Synonyms | C1orf215|LAP18|Lag|OP18|PP17|PP19|PR22|SMN | GTT1 | |
| Cytomap | 1p36.11 | 2q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | stathminleukemia-associated phosphoprotein p18metablastinoncoprotein 18phosphoprotein 19phosphoprotein p19prosolinstathmin 1/oncoprotein 18testicular tissue protein Li 189transmembrane protein C1orf215 | stAR-related lipid transfer protein 7, mitochondrialSTART domain containing 7START domain-containing protein 7StAR-related lipid transfer (START) domain containing 7gestational trophoblastic tumor protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P16949 | Q9NQZ5 | |
| Ensembl transtripts involved in fusion gene | ENST00000426559, ENST00000455785, ENST00000399728, ENST00000465604, ENST00000357865, ENST00000374291, | ENST00000337288, ENST00000462501, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 6 X 6 X 2=72 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: STMN1 [Title/Abstract] AND STARD7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STMN1 | GO:0007019 | microtubule depolymerization | 9880330 |
| Hgene | STMN1 | GO:0007052 | mitotic spindle organization | 9271428 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ946944 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000426559 | ENST00000337288 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
| intron-intron | ENST00000426559 | ENST00000462501 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
| intron-5UTR | ENST00000455785 | ENST00000337288 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
| intron-intron | ENST00000455785 | ENST00000462501 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
| intron-5UTR | ENST00000399728 | ENST00000337288 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
| intron-intron | ENST00000399728 | ENST00000462501 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
| intron-5UTR | ENST00000465604 | ENST00000337288 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
| intron-intron | ENST00000465604 | ENST00000462501 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
| intron-5UTR | ENST00000357865 | ENST00000337288 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
| intron-intron | ENST00000357865 | ENST00000462501 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
| intron-5UTR | ENST00000374291 | ENST00000337288 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
| intron-intron | ENST00000374291 | ENST00000462501 | STMN1 | chr1 | 26232898 | + | STARD7 | chr2 | 96874546 | - |
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FusionProtFeatures for STMN1_STARD7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STMN1 | STARD7 |