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Fusion gene ID: 36497 |
FusionGeneSummary for STK24_MPC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STK24_MPC2 | Fusion gene ID: 36497 | Hgene | Tgene | Gene symbol | STK24 | MPC2 | Gene ID | 8428 | 25874 |
| Gene name | serine/threonine kinase 24 | mitochondrial pyruvate carrier 2 | |
| Synonyms | HEL-S-95|MST3|MST3B|STE20|STK3 | BRP44|SLC54A2 | |
| Cytomap | 13q32.2 | 1q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3 | mitochondrial pyruvate carrier 2brain protein 44 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y6E0 | O95563 | |
| Ensembl transtripts involved in fusion gene | ENST00000397517, ENST00000539966, ENST00000481288, ENST00000376547, | ENST00000367846, ENST00000271373, | |
| Fusion gene scores | * DoF score | 11 X 5 X 9=495 | 6 X 4 X 5=120 |
| # samples | 18 | 6 | |
| ** MAII score | log2(18/495*10)=-1.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: STK24 [Title/Abstract] AND MPC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STK24 | GO:0006468 | protein phosphorylation | 19604147 |
| Hgene | STK24 | GO:0042542 | response to hydrogen peroxide | 22291017 |
| Hgene | STK24 | GO:0046777 | protein autophosphorylation | 17046825|17657516 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-BF-AAP7-01A | STK24 | chr13 | 99228999 | - | MPC2 | chr1 | 167893775 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000397517 | ENST00000367846 | STK24 | chr13 | 99228999 | - | MPC2 | chr1 | 167893775 | - |
| Frame-shift | ENST00000397517 | ENST00000271373 | STK24 | chr13 | 99228999 | - | MPC2 | chr1 | 167893775 | - |
| Frame-shift | ENST00000539966 | ENST00000367846 | STK24 | chr13 | 99228999 | - | MPC2 | chr1 | 167893775 | - |
| Frame-shift | ENST00000539966 | ENST00000271373 | STK24 | chr13 | 99228999 | - | MPC2 | chr1 | 167893775 | - |
| intron-3CDS | ENST00000481288 | ENST00000367846 | STK24 | chr13 | 99228999 | - | MPC2 | chr1 | 167893775 | - |
| intron-3CDS | ENST00000481288 | ENST00000271373 | STK24 | chr13 | 99228999 | - | MPC2 | chr1 | 167893775 | - |
| intron-3CDS | ENST00000376547 | ENST00000367846 | STK24 | chr13 | 99228999 | - | MPC2 | chr1 | 167893775 | - |
| intron-3CDS | ENST00000376547 | ENST00000271373 | STK24 | chr13 | 99228999 | - | MPC2 | chr1 | 167893775 | - |
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FusionProtFeatures for STK24_MPC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STK24 | MPC2 |