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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 36454

FusionGeneSummary for STIM1_NUP98

check button Fusion gene summary
Fusion gene informationFusion gene name: STIM1_NUP98
Fusion gene ID: 36454
HgeneTgene
Gene symbol

STIM1

NUP98

Gene ID

6786

4928

Gene namestromal interaction molecule 1nucleoporin 98
SynonymsD11S4896E|GOK|IMD10|STRMK|TAM|TAM1ADIR2|NUP196|NUP96
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionstromal interaction molecule 1nuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 98kDnucleoporin 98kDa
Modification date2018052720180523
UniProtAcc

Q13586

P52948

Ensembl transtripts involved in fusion geneENST00000300737, ENST00000527651, 
ENST00000527484, ENST00000533977, 
ENST00000324932, ENST00000359171, 
ENST00000355260, ENST00000397004, 
ENST00000397007, ENST00000488828, 
Fusion gene scores* DoF score12 X 8 X 8=7689 X 9 X 5=405
# samples 1211
** MAII scorelog2(12/768*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/405*10)=-1.88041838424733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STIM1 [Title/Abstract] AND NUP98 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTIM1

GO:0002115

store-operated calcium entry

28219928

HgeneSTIM1

GO:0005513

detection of calcium ion

16005298

HgeneSTIM1

GO:0032237

activation of store-operated calcium channel activity

16005298|26322679|28219928

HgeneSTIM1

GO:0051924

regulation of calcium ion transport

16005298


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-93-A4JP-01ASTIM1chr11

3968954

+NUP98chr11

3765879

-
TCGALDLUADTCGA-93-A4JP-01ASTIM1chr11

3877639

+NUP98chr11

3756554

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000300737ENST00000324932STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000300737ENST00000359171STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000300737ENST00000355260STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000300737ENST00000397004STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000300737ENST00000397007STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-intronENST00000300737ENST00000488828STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000527651ENST00000324932STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000527651ENST00000359171STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000527651ENST00000355260STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000527651ENST00000397004STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000527651ENST00000397007STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-intronENST00000527651ENST00000488828STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000527484ENST00000324932STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000527484ENST00000359171STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000527484ENST00000355260STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000527484ENST00000397004STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000527484ENST00000397007STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-intronENST00000527484ENST00000488828STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000533977ENST00000324932STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000533977ENST00000359171STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000533977ENST00000355260STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000533977ENST00000397004STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-3CDSENST00000533977ENST00000397007STIM1chr11

3968954

+NUP98chr11

3765879

-
intron-intronENST00000533977ENST00000488828STIM1chr11

3968954

+NUP98chr11

3765879

-
In-frameENST00000300737ENST00000324932STIM1chr11

3877639

+NUP98chr11

3756554

-
In-frameENST00000300737ENST00000359171STIM1chr11

3877639

+NUP98chr11

3756554

-
In-frameENST00000300737ENST00000355260STIM1chr11

3877639

+NUP98chr11

3756554

-
In-frameENST00000300737ENST00000397004STIM1chr11

3877639

+NUP98chr11

3756554

-
In-frameENST00000300737ENST00000397007STIM1chr11

3877639

+NUP98chr11

3756554

-
5CDS-intronENST00000300737ENST00000488828STIM1chr11

3877639

+NUP98chr11

3756554

-
In-frameENST00000527651ENST00000324932STIM1chr11

3877639

+NUP98chr11

3756554

-
In-frameENST00000527651ENST00000359171STIM1chr11

3877639

+NUP98chr11

3756554

-
In-frameENST00000527651ENST00000355260STIM1chr11

3877639

+NUP98chr11

3756554

-
In-frameENST00000527651ENST00000397004STIM1chr11

3877639

+NUP98chr11

3756554

-
In-frameENST00000527651ENST00000397007STIM1chr11

3877639

+NUP98chr11

3756554

-
5CDS-intronENST00000527651ENST00000488828STIM1chr11

3877639

+NUP98chr11

3756554

-
intron-3CDSENST00000527484ENST00000324932STIM1chr11

3877639

+NUP98chr11

3756554

-
intron-3CDSENST00000527484ENST00000359171STIM1chr11

3877639

+NUP98chr11

3756554

-
intron-3CDSENST00000527484ENST00000355260STIM1chr11

3877639

+NUP98chr11

3756554

-
intron-3CDSENST00000527484ENST00000397004STIM1chr11

3877639

+NUP98chr11

3756554

-
intron-3CDSENST00000527484ENST00000397007STIM1chr11

3877639

+NUP98chr11

3756554

-
intron-intronENST00000527484ENST00000488828STIM1chr11

3877639

+NUP98chr11

3756554

-
intron-3CDSENST00000533977ENST00000324932STIM1chr11

3877639

+NUP98chr11

3756554

-
intron-3CDSENST00000533977ENST00000359171STIM1chr11

3877639

+NUP98chr11

3756554

-
intron-3CDSENST00000533977ENST00000355260STIM1chr11

3877639

+NUP98chr11

3756554

-
intron-3CDSENST00000533977ENST00000397004STIM1chr11

3877639

+NUP98chr11

3756554

-
intron-3CDSENST00000533977ENST00000397007STIM1chr11

3877639

+NUP98chr11

3756554

-
intron-intronENST00000533977ENST00000488828STIM1chr11

3877639

+NUP98chr11

3756554

-

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FusionProtFeatures for STIM1_NUP98


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STIM1

Q13586

NUP98

P52948