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Fusion gene ID: 36448 |
FusionGeneSummary for STIM1_ANO9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STIM1_ANO9 | Fusion gene ID: 36448 | Hgene | Tgene | Gene symbol | STIM1 | ANO9 | Gene ID | 6786 | 338440 |
| Gene name | stromal interaction molecule 1 | anoctamin 9 | |
| Synonyms | D11S4896E|GOK|IMD10|STRMK|TAM|TAM1 | PIG5|TMEM16J|TP53I5 | |
| Cytomap | 11p15.4 | 11p15.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | stromal interaction molecule 1 | anoctamin-9p53-induced gene 5 proteintransmembrane protein 16Jtumor protein p53-inducible protein 5 | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | Q13586 | A1A5B4 | |
| Ensembl transtripts involved in fusion gene | ENST00000300737, ENST00000527651, ENST00000527484, ENST00000533977, | ENST00000332826, | |
| Fusion gene scores | * DoF score | 12 X 8 X 8=768 | 3 X 3 X 3=27 |
| # samples | 12 | 3 | |
| ** MAII score | log2(12/768*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: STIM1 [Title/Abstract] AND ANO9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STIM1 | GO:0002115 | store-operated calcium entry | 28219928 |
| Hgene | STIM1 | GO:0005513 | detection of calcium ion | 16005298 |
| Hgene | STIM1 | GO:0032237 | activation of store-operated calcium channel activity | 16005298|26322679|28219928 |
| Hgene | STIM1 | GO:0051924 | regulation of calcium ion transport | 16005298 |
| Tgene | ANO9 | GO:1902939 | negative regulation of intracellular calcium activated chloride channel activity | 22946059 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-TQ-A7RV-01A | STIM1 | chr11 | 4045217 | + | ANO9 | chr11 | 434098 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000300737 | ENST00000332826 | STIM1 | chr11 | 4045217 | + | ANO9 | chr11 | 434098 | - |
| Frame-shift | ENST00000527651 | ENST00000332826 | STIM1 | chr11 | 4045217 | + | ANO9 | chr11 | 434098 | - |
| 3UTR-3CDS | ENST00000527484 | ENST00000332826 | STIM1 | chr11 | 4045217 | + | ANO9 | chr11 | 434098 | - |
| intron-3CDS | ENST00000533977 | ENST00000332826 | STIM1 | chr11 | 4045217 | + | ANO9 | chr11 | 434098 | - |
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FusionProtFeatures for STIM1_ANO9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STIM1 | ANO9 |