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Fusion gene ID: 36390 |
FusionGeneSummary for STAT5A_ARNTL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STAT5A_ARNTL2 | Fusion gene ID: 36390 | Hgene | Tgene | Gene symbol | STAT5A | ARNTL2 | Gene ID | 6776 | 56938 |
| Gene name | signal transducer and activator of transcription 5A | aryl hydrocarbon receptor nuclear translocator like 2 | |
| Synonyms | MGF|STAT5 | BMAL2|CLIF|MOP9|PASD9|bHLHe6 | |
| Cytomap | 17q21.2 | 12p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | signal transducer and activator of transcription 5A | aryl hydrocarbon receptor nuclear translocator-like protein 2CYCLE-like factorPAS domain-containing protein 9basic-helix-loop-helix-PAS protein MOP9brain and muscle ARNT-like 2class E basic helix-loop-helix protein 6member of PAS protein 9transcrip | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P42229 | Q8WYA1 | |
| Ensembl transtripts involved in fusion gene | ENST00000345506, ENST00000590949, ENST00000546010, ENST00000452307, ENST00000588868, ENST00000587646, | ENST00000544915, ENST00000395901, ENST00000546179, ENST00000311001, ENST00000261178, ENST00000266503, ENST00000539558, ENST00000542388, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 3 X 3=27 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: STAT5A [Title/Abstract] AND ARNTL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ARNTL2 | GO:0006357 | regulation of transcription by RNA polymerase II | 12055078 |
| Tgene | ARNTL2 | GO:0007623 | circadian rhythm | 10864977 |
| Tgene | ARNTL2 | GO:0045893 | positive regulation of transcription, DNA-templated | 12738229 |
| Tgene | ARNTL2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15147242 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-J2-A4AD-01A | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000345506 | ENST00000544915 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000345506 | ENST00000395901 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000345506 | ENST00000546179 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000345506 | ENST00000311001 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000345506 | ENST00000261178 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000345506 | ENST00000266503 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| 5CDS-intron | ENST00000345506 | ENST00000539558 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| 5CDS-intron | ENST00000345506 | ENST00000542388 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000590949 | ENST00000544915 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000590949 | ENST00000395901 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000590949 | ENST00000546179 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000590949 | ENST00000311001 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000590949 | ENST00000261178 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000590949 | ENST00000266503 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| 5CDS-intron | ENST00000590949 | ENST00000539558 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| 5CDS-intron | ENST00000590949 | ENST00000542388 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000546010 | ENST00000544915 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000546010 | ENST00000395901 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000546010 | ENST00000546179 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000546010 | ENST00000311001 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000546010 | ENST00000261178 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000546010 | ENST00000266503 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| 5CDS-intron | ENST00000546010 | ENST00000539558 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| 5CDS-intron | ENST00000546010 | ENST00000542388 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000452307 | ENST00000544915 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000452307 | ENST00000395901 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000452307 | ENST00000546179 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000452307 | ENST00000311001 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000452307 | ENST00000261178 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000452307 | ENST00000266503 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| 5CDS-intron | ENST00000452307 | ENST00000539558 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| 5CDS-intron | ENST00000452307 | ENST00000542388 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000588868 | ENST00000544915 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000588868 | ENST00000395901 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000588868 | ENST00000546179 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000588868 | ENST00000311001 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000588868 | ENST00000261178 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| In-frame | ENST00000588868 | ENST00000266503 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| 5CDS-intron | ENST00000588868 | ENST00000539558 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| 5CDS-intron | ENST00000588868 | ENST00000542388 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| intron-3CDS | ENST00000587646 | ENST00000544915 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| intron-3CDS | ENST00000587646 | ENST00000395901 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| intron-3CDS | ENST00000587646 | ENST00000546179 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| intron-3CDS | ENST00000587646 | ENST00000311001 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| intron-3CDS | ENST00000587646 | ENST00000261178 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| intron-3CDS | ENST00000587646 | ENST00000266503 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| intron-intron | ENST00000587646 | ENST00000539558 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
| intron-intron | ENST00000587646 | ENST00000542388 | STAT5A | chr17 | 40447811 | + | ARNTL2 | chr12 | 27538414 | + |
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FusionProtFeatures for STAT5A_ARNTL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STAT5A | ARNTL2 |