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Fusion gene ID: 36385 |
FusionGeneSummary for STAT3_NOS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STAT3_NOS2 | Fusion gene ID: 36385 | Hgene | Tgene | Gene symbol | STAT3 | NOS2 | Gene ID | 6774 | 4843 |
| Gene name | signal transducer and activator of transcription 3 | nitric oxide synthase 2 | |
| Synonyms | ADMIO|ADMIO1|APRF|HIES | HEP-NOS|INOS|NOS|NOS2A | |
| Cytomap | 17q21.2 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | signal transducer and activator of transcription 3DNA-binding protein APRFacute-phase response factor | nitric oxide synthase, inducibleNOS, type IIhepatocyte NOSinducible NO synthaseinducible NOSnitric oxide synthase 2, induciblenitric oxide synthase 2A (inducible, hepatocytes)nitric oxide synthase, macrophagepeptidyl-cysteine S-nitrosylase NOS2 | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | P40763 | P35228 | |
| Ensembl transtripts involved in fusion gene | ENST00000264657, ENST00000585517, ENST00000389272, ENST00000588969, ENST00000404395, ENST00000590776, | ENST00000313735, | |
| Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 4 X 3 X 3=36 |
| # samples | 8 | 3 | |
| ** MAII score | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: STAT3 [Title/Abstract] AND NOS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STAT3 | GO:0006355 | regulation of transcription, DNA-templated | 15664994|17344214 |
| Hgene | STAT3 | GO:0006606 | protein import into nucleus | 18234692 |
| Hgene | STAT3 | GO:0010628 | positive regulation of gene expression | 23820254 |
| Hgene | STAT3 | GO:0030522 | intracellular receptor signaling pathway | 17324931 |
| Hgene | STAT3 | GO:0032355 | response to estradiol | 12552091 |
| Hgene | STAT3 | GO:0032870 | cellular response to hormone stimulus | 12552091 |
| Hgene | STAT3 | GO:0033210 | leptin-mediated signaling pathway | 17344214 |
| Hgene | STAT3 | GO:0035278 | miRNA mediated inhibition of translation | 23820254 |
| Hgene | STAT3 | GO:0044320 | cellular response to leptin stimulus | 17344214 |
| Hgene | STAT3 | GO:0044321 | response to leptin | 17344214 |
| Hgene | STAT3 | GO:0045893 | positive regulation of transcription, DNA-templated | 19390056 |
| Hgene | STAT3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17324931 |
| Hgene | STAT3 | GO:0051726 | regulation of cell cycle | 17344214 |
| Hgene | STAT3 | GO:0060396 | growth hormone receptor signaling pathway | 10925297 |
| Hgene | STAT3 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | 12552091 |
| Hgene | STAT3 | GO:0070102 | interleukin-6-mediated signaling pathway | 12359225|12552091|17324931 |
| Hgene | STAT3 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 19390056|23820254 |
| Hgene | STAT3 | GO:2000637 | positive regulation of gene silencing by miRNA | 23820254 |
| Tgene | NOS2 | GO:0006527 | arginine catabolic process | 7504305 |
| Tgene | NOS2 | GO:0006809 | nitric oxide biosynthetic process | 7504305|7682706 |
| Tgene | NOS2 | GO:0032310 | prostaglandin secretion | 19688109 |
| Tgene | NOS2 | GO:0072604 | interleukin-6 secretion | 19688109 |
| Tgene | NOS2 | GO:0072606 | interleukin-8 secretion | 19688109 |
| Tgene | NOS2 | GO:1900015 | regulation of cytokine production involved in inflammatory response | 19688109 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-L5-A4OW-01A | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000264657 | ENST00000313735 | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| 5UTR-3CDS | ENST00000585517 | ENST00000313735 | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| 5UTR-3CDS | ENST00000389272 | ENST00000313735 | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| 5UTR-3CDS | ENST00000588969 | ENST00000313735 | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| 5UTR-3CDS | ENST00000404395 | ENST00000313735 | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
| intron-3CDS | ENST00000590776 | ENST00000313735 | STAT3 | chr17 | 40540297 | - | NOS2 | chr17 | 26116714 | - |
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FusionProtFeatures for STAT3_NOS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STAT3 | NOS2 |