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Fusion gene ID: 36361

FusionGeneSummary for STARD3_UVRAG

Fusion gene summary

Fusion gene information	Fusion gene name: STARD3_UVRAG
	Fusion gene ID: 36361
		Hgene	Tgene
	Gene symbol	STARD3	UVRAG
	Gene ID	10948	7405
	Gene name	StAR related lipid transfer domain containing 3	UV radiation resistance associated
	Synonyms	CAB1\|MLN64\|es64	DHTX\|VPS38\|p63
	Cytomap	17q12	11q13.5
	Type of gene	protein-coding	protein-coding
	Description	stAR-related lipid transfer protein 3MLN 64START domain-containing protein 3StAR-related lipid transfer (START) domain containing 3metastatic lymph node gene 64 proteinmetastatic lymph node protein 64steroidogenic acute regulatory protein related	UV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxy
	Modification date	20180522	20180523
	UniProtAcc	Q14849	Q9P2Y5
	Ensembl transtripts involved in fusion gene	ENST00000336308, ENST00000578232, ENST00000544210, ENST00000394250, ENST00000580611,	ENST00000356136, ENST00000528420, ENST00000533454, ENST00000531818, ENST00000532130, ENST00000539288, ENST00000525872, ENST00000538870,
Fusion gene scores	* DoF score	21 X 6 X 7=882	24 X 13 X 11=3432
	# samples	22	25
	** MAII score	log2(22/882*10)=-2.00327513203286 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(25/3432*10)=-3.77904955283746 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: STARD3 [Title/Abstract] AND UVRAG [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	STARD3	GO:0030301	cholesterol transport	28377464
Hgene	STARD3	GO:0099044	vesicle tethering to endoplasmic reticulum	24105263\|28377464
Tgene	UVRAG	GO:0071900	regulation of protein serine/threonine kinase activity	22542840
Tgene	UVRAG	GO:0097680	double-strand break repair via classical nonhomologous end joining	22542840

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-A1-A0SM-01A	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000336308	ENST00000356136	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
In-frame	ENST00000336308	ENST00000528420	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000336308	ENST00000533454	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000336308	ENST00000531818	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000336308	ENST00000532130	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000336308	ENST00000539288	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000336308	ENST00000525872	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000336308	ENST00000538870	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
3UTR-3CDS	ENST00000578232	ENST00000356136	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
3UTR-3CDS	ENST00000578232	ENST00000528420	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
3UTR-intron	ENST00000578232	ENST00000533454	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
3UTR-intron	ENST00000578232	ENST00000531818	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
3UTR-intron	ENST00000578232	ENST00000532130	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
3UTR-intron	ENST00000578232	ENST00000539288	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
3UTR-intron	ENST00000578232	ENST00000525872	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
3UTR-intron	ENST00000578232	ENST00000538870	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
In-frame	ENST00000544210	ENST00000356136	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
In-frame	ENST00000544210	ENST00000528420	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000544210	ENST00000533454	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000544210	ENST00000531818	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000544210	ENST00000532130	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000544210	ENST00000539288	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000544210	ENST00000525872	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000544210	ENST00000538870	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
In-frame	ENST00000394250	ENST00000356136	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
In-frame	ENST00000394250	ENST00000528420	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000394250	ENST00000533454	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000394250	ENST00000531818	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000394250	ENST00000532130	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000394250	ENST00000539288	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000394250	ENST00000525872	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000394250	ENST00000538870	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
In-frame	ENST00000580611	ENST00000356136	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
In-frame	ENST00000580611	ENST00000528420	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000580611	ENST00000533454	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000580611	ENST00000531818	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000580611	ENST00000532130	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000580611	ENST00000539288	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000580611	ENST00000525872	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+
5CDS-intron	ENST00000580611	ENST00000538870	STARD3	chr17	37810003	+	UVRAG	chr11	75599873	+

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FusionProtFeatures for STARD3_UVRAG

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
STARD3 Q14849	UVRAG Q9P2Y5

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Fusion gene ID: 36361

FusionGeneSummary for STARD3_UVRAG

FusionProtFeatures for STARD3_UVRAG