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Fusion gene ID: 36262 |
FusionGeneSummary for ST6GALNAC3_AK5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ST6GALNAC3_AK5 | Fusion gene ID: 36262 | Hgene | Tgene | Gene symbol | ST6GALNAC3 | AK5 | Gene ID | 256435 | 26289 |
| Gene name | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | adenylate kinase 5 | |
| Synonyms | PRO7177|SIAT7C|ST6GALNACIII|STY | AK6 | |
| Cytomap | 1p31.1 | 1p31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3GalNAc alpha-2,6-sialyltransferase IIIST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltranST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3) | adenylate kinase isoenzyme 5AK 5ATP-AMP transphosphorylase 5adenylate kinase 6 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8NDV1 | Q9Y6K8 | |
| Ensembl transtripts involved in fusion gene | ENST00000328299, ENST00000464140, | ENST00000354567, ENST00000344720, ENST00000317704, ENST00000478255, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 3 X 4=60 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ST6GALNAC3 [Title/Abstract] AND AK5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ST6GALNAC3 | GO:0006677 | glycosylceramide metabolic process | 17123352 |
| Hgene | ST6GALNAC3 | GO:0006687 | glycosphingolipid metabolic process | 17123352 |
| Hgene | ST6GALNAC3 | GO:0009100 | glycoprotein metabolic process | 17123352 |
| Tgene | AK5 | GO:0006165 | nucleoside diphosphate phosphorylation | 23416111 |
| Tgene | AK5 | GO:0009142 | nucleoside triphosphate biosynthetic process | 23416111 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-LA-A7SW-01A | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000328299 | ENST00000354567 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| In-frame | ENST00000328299 | ENST00000344720 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| 5CDS-intron | ENST00000328299 | ENST00000317704 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| 5CDS-intron | ENST00000328299 | ENST00000478255 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| intron-3CDS | ENST00000464140 | ENST00000354567 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| intron-3CDS | ENST00000464140 | ENST00000344720 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| intron-intron | ENST00000464140 | ENST00000317704 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
| intron-intron | ENST00000464140 | ENST00000478255 | ST6GALNAC3 | chr1 | 76540569 | + | AK5 | chr1 | 77949002 | + |
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FusionProtFeatures for ST6GALNAC3_AK5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ST6GALNAC3 | AK5 |