|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 36253 |
FusionGeneSummary for ST6GAL1_LPP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ST6GAL1_LPP | Fusion gene ID: 36253 | Hgene | Tgene | Gene symbol | ST6GAL1 | LPP | Gene ID | 6480 | 4026 |
| Gene name | ST6 beta-galactoside alpha-2,6-sialyltransferase 1 | LIM domain containing preferred translocation partner in lipoma | |
| Synonyms | SIAT1|ST6GalI|ST6N | - | |
| Cytomap | 3q27.3 | 3q27.3-q28 | |
| Type of gene | protein-coding | protein-coding | |
| Description | beta-galactoside alpha-2,6-sialyltransferase 1B-cell antigen CD75CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferaseCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1ST6 N-acetylgalactosaminide alpha-2,6-sialyl | lipoma-preferred partnerLIM proteinlipoma preferred partner | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P15907 | Q93052 | |
| Ensembl transtripts involved in fusion gene | ENST00000169298, ENST00000457772, ENST00000448044, ENST00000487031, | ENST00000448637, ENST00000312675, ENST00000543006, ENST00000471917, | |
| Fusion gene scores | * DoF score | 5 X 3 X 6=90 | 12 X 17 X 5=1020 |
| # samples | 6 | 20 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1020*10)=-2.35049724708413 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ST6GAL1 [Title/Abstract] AND LPP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ST6GAL1 | GO:0006054 | N-acetylneuraminate metabolic process | 23999306 |
| Hgene | ST6GAL1 | GO:0018279 | protein N-linked glycosylation via asparagine | 23999306 |
| Hgene | ST6GAL1 | GO:0097503 | sialylation | 23999306 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-DZ-6131-01A | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000169298 | ENST00000448637 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000169298 | ENST00000312675 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000169298 | ENST00000543006 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000169298 | ENST00000471917 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000457772 | ENST00000448637 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000457772 | ENST00000312675 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000457772 | ENST00000543006 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000457772 | ENST00000471917 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000448044 | ENST00000448637 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000448044 | ENST00000312675 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000448044 | ENST00000543006 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000448044 | ENST00000471917 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000487031 | ENST00000448637 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000487031 | ENST00000312675 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000487031 | ENST00000543006 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000487031 | ENST00000471917 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
Top |
FusionProtFeatures for ST6GAL1_LPP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ST6GAL1 | LPP |