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Fusion gene ID: 36247

FusionGeneSummary for ST3GAL5_ST3GAL5

Fusion gene summary

Fusion gene information	Fusion gene name: ST3GAL5_ST3GAL5
	Fusion gene ID: 36247
		Hgene	Tgene
	Gene symbol	ST3GAL5	ST3GAL5
	Gene ID	8869	8869
	Gene name	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5
	Synonyms	SATI\|SIAT9\|SIATGM3S\|SPDRS\|ST3Gal V\|ST3GalV	SATI\|SIAT9\|SIATGM3S\|SPDRS\|ST3Gal V\|ST3GalV
	Cytomap	2p11.2	2p11.2
	Type of gene	protein-coding	protein-coding
	Description	lactosylceramide alpha-2,3-sialyltransferaseCMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferaseST3 beta-galactoside alpha-23-sialyltransferase 5alpha 2,3-sialyltransferase Vganglioside GM3 synthasesialyltransferase 9 (CMP-NeuAc:lactosylceramide al	lactosylceramide alpha-2,3-sialyltransferaseCMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferaseST3 beta-galactoside alpha-23-sialyltransferase 5alpha 2,3-sialyltransferase Vganglioside GM3 synthasesialyltransferase 9 (CMP-NeuAc:lactosylceramide al
	Modification date	20180523	20180523
	UniProtAcc	Q9UNP4	Q9UNP4
	Ensembl transtripts involved in fusion gene	ENST00000393805, ENST00000377332, ENST00000525834, ENST00000484728, ENST00000393808,	ENST00000393805, ENST00000377332, ENST00000525834, ENST00000484728, ENST00000393808,
Fusion gene scores	* DoF score	3 X 3 X 2=18	2 X 2 X 2=8
	# samples	4	3
	** MAII score	log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(3/8*10)=1.90689059560852
Context	PubMed: ST3GAL5 [Title/Abstract] AND ST3GAL5 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF933062	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
ChiTaRS3.1			BF933057	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000393805	ENST00000393805	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000393805	ENST00000377332	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000393805	ENST00000525834	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000393805	ENST00000484728	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000393805	ENST00000393808	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000377332	ENST00000393805	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000377332	ENST00000377332	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000377332	ENST00000525834	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000377332	ENST00000484728	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000377332	ENST00000393808	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000525834	ENST00000393805	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000525834	ENST00000377332	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000525834	ENST00000525834	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000525834	ENST00000484728	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000525834	ENST00000393808	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000484728	ENST00000393805	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000484728	ENST00000377332	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000484728	ENST00000525834	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000484728	ENST00000484728	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000484728	ENST00000393808	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000393808	ENST00000393805	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000393808	ENST00000377332	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000393808	ENST00000525834	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000393808	ENST00000484728	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+
intron-intron	ENST00000393808	ENST00000393808	ST3GAL5	chr2	86106184	-	ST3GAL5	chr2	86106439	+

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FusionProtFeatures for ST3GAL5_ST3GAL5

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ST3GAL5 Q9UNP4	ST3GAL5 Q9UNP4

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Fusion gene ID: 36247

FusionGeneSummary for ST3GAL5_ST3GAL5

FusionProtFeatures for ST3GAL5_ST3GAL5