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Fusion gene ID: 36246 |
FusionGeneSummary for ST3GAL5_KCMF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ST3GAL5_KCMF1 | Fusion gene ID: 36246 | Hgene | Tgene | Gene symbol | ST3GAL5 | KCMF1 | Gene ID | 8869 | 56888 |
| Gene name | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | potassium channel modulatory factor 1 | |
| Synonyms | SATI|SIAT9|SIATGM3S|SPDRS|ST3Gal V|ST3GalV | DEBT91|FIGC|PCMF|ZZZ1 | |
| Cytomap | 2p11.2 | 2p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lactosylceramide alpha-2,3-sialyltransferaseCMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferaseST3 beta-galactoside alpha-23-sialyltransferase 5alpha 2,3-sialyltransferase Vganglioside GM3 synthasesialyltransferase 9 (CMP-NeuAc:lactosylceramide al | E3 ubiquitin-protein ligase KCMF1FGF-induced in gastric cancerFGF-induced ubiquitin-protein ligase in gastric cancersRING-type E3 ubiquitin transferase KCMF1ZZ-type zinc finger-containing protein 1differentially expressed in branching tubulogenesis 9 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UNP4 | Q9P0J7 | |
| Ensembl transtripts involved in fusion gene | ENST00000393805, ENST00000377332, ENST00000525834, ENST00000484728, ENST00000393808, | ENST00000409785, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 5 X 3=75 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/75*10)=-0.0995356735509144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ST3GAL5 [Title/Abstract] AND KCMF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI462676 | ST3GAL5 | chr2 | 86115945 | - | KCMF1 | chr2 | 85255010 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000393805 | ENST00000409785 | ST3GAL5 | chr2 | 86115945 | - | KCMF1 | chr2 | 85255010 | + |
| Frame-shift | ENST00000377332 | ENST00000409785 | ST3GAL5 | chr2 | 86115945 | - | KCMF1 | chr2 | 85255010 | + |
| Frame-shift | ENST00000525834 | ENST00000409785 | ST3GAL5 | chr2 | 86115945 | - | KCMF1 | chr2 | 85255010 | + |
| 5UTR-3CDS | ENST00000484728 | ENST00000409785 | ST3GAL5 | chr2 | 86115945 | - | KCMF1 | chr2 | 85255010 | + |
| intron-3CDS | ENST00000393808 | ENST00000409785 | ST3GAL5 | chr2 | 86115945 | - | KCMF1 | chr2 | 85255010 | + |
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FusionProtFeatures for ST3GAL5_KCMF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ST3GAL5 | KCMF1 |