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Fusion gene ID: 3623 |
FusionGeneSummary for AUTS2_ENPP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AUTS2_ENPP2 | Fusion gene ID: 3623 | Hgene | Tgene | Gene symbol | AUTS2 | ENPP2 | Gene ID | 26053 | 5168 |
| Gene name | AUTS2, activator of transcription and developmental regulator | ectonucleotide pyrophosphatase/phosphodiesterase 2 | |
| Synonyms | FBRSL2|MRD26 | ATX|ATX-X|AUTOTAXIN|LysoPLD|NPP2|PD-IALPHA|PDNP2 | |
| Cytomap | 7q11.22 | 8q24.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | autism susceptibility gene 2 proteinautism susceptibility candidate 2autism-related protein 1 | ectonucleotide pyrophosphatase/phosphodiesterase family member 2E-NPP 2autotaxin-textracellular lysophospholipase Dphosphodiesterase I/nucleotide pyrophosphatase 2plasma lysophospholipase D | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8WXX7 | Q13822 | |
| Ensembl transtripts involved in fusion gene | ENST00000406775, ENST00000342771, ENST00000403018, ENST00000489774, | ENST00000259486, ENST00000427067, ENST00000522167, ENST00000522826, ENST00000075322, ENST00000518109, | |
| Fusion gene scores | * DoF score | 19 X 15 X 7=1995 | 6 X 6 X 3=108 |
| # samples | 19 | 6 | |
| ** MAII score | log2(19/1995*10)=-3.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AUTS2 [Title/Abstract] AND ENPP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AUTS2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 25519132 |
| Hgene | AUTS2 | GO:0051571 | positive regulation of histone H3-K4 methylation | 25519132 |
| Hgene | AUTS2 | GO:2000620 | positive regulation of histone H4-K16 acetylation | 25519132 |
| Tgene | ENPP2 | GO:0009395 | phospholipid catabolic process | 15280042 |
| Tgene | ENPP2 | GO:0030334 | regulation of cell migration | 1733949 |
| Tgene | ENPP2 | GO:0034638 | phosphatidylcholine catabolic process | 21240271 |
| Tgene | ENPP2 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 18054784 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AV754461 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000406775 | ENST00000259486 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000406775 | ENST00000427067 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000406775 | ENST00000522167 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000406775 | ENST00000522826 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000406775 | ENST00000075322 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000406775 | ENST00000518109 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000342771 | ENST00000259486 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000342771 | ENST00000427067 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000342771 | ENST00000522167 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000342771 | ENST00000522826 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000342771 | ENST00000075322 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000342771 | ENST00000518109 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000403018 | ENST00000259486 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000403018 | ENST00000427067 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000403018 | ENST00000522167 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000403018 | ENST00000522826 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000403018 | ENST00000075322 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000403018 | ENST00000518109 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000489774 | ENST00000259486 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000489774 | ENST00000427067 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000489774 | ENST00000522167 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000489774 | ENST00000522826 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000489774 | ENST00000075322 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
| intron-intron | ENST00000489774 | ENST00000518109 | AUTS2 | chr7 | 69813447 | + | ENPP2 | chr8 | 120600550 | - |
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FusionProtFeatures for AUTS2_ENPP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AUTS2 | ENPP2 |