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Fusion gene ID: 36187 |
FusionGeneSummary for SSR2_SUPT16H |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SSR2_SUPT16H | Fusion gene ID: 36187 | Hgene | Tgene | Gene symbol | SSR2 | SUPT16H | Gene ID | 6746 | 11198 |
| Gene name | signal sequence receptor subunit 2 | SPT16 homolog, facilitates chromatin remodeling subunit | |
| Synonyms | HSD25|TLAP|TRAP-BETA|TRAPB | CDC68|FACTP140|SPT16|SPT16/CDC68 | |
| Cytomap | 1q22 | 14q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | translocon-associated protein subunit betaSSR-betasignal sequence receptor subunit betasignal sequence receptor, beta (translocon-associated protein beta)translocon-associated protein beta | FACT complex subunit SPT16FACT 140 kDa subunitchromatin-specific transcription elongation factor 140 kDa subunitfacilitates chromatin remodeling 140 kDa subunitfacilitates chromatin transcription complex subunit SPT16hSPT16suppressor of Ty 16 homolo | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P43308 | Q9Y5B9 | |
| Ensembl transtripts involved in fusion gene | ENST00000295702, ENST00000529008, ENST00000496742, ENST00000480567, | ENST00000216297, ENST00000555943, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 37 X 4 X 15=2220 |
| # samples | 5 | 40 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(40/2220*10)=-2.47248777146274 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SSR2 [Title/Abstract] AND SUPT16H [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-8687-01A | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000295702 | ENST00000216297 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
| 5CDS-intron | ENST00000295702 | ENST00000555943 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
| intron-intron | ENST00000529008 | ENST00000216297 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
| intron-intron | ENST00000529008 | ENST00000555943 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
| intron-intron | ENST00000496742 | ENST00000216297 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
| intron-intron | ENST00000496742 | ENST00000555943 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
| intron-intron | ENST00000480567 | ENST00000216297 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
| intron-intron | ENST00000480567 | ENST00000555943 | SSR2 | chr1 | 155978839 | - | SUPT16H | chr14 | 21829491 | - |
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FusionProtFeatures for SSR2_SUPT16H |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SSR2 | SUPT16H |