|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 36148 |
FusionGeneSummary for SSH2_ASAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SSH2_ASAP1 | Fusion gene ID: 36148 | Hgene | Tgene | Gene symbol | SSH2 | ASAP1 | Gene ID | 85464 | 50807 |
| Gene name | slingshot protein phosphatase 2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | |
| Synonyms | SSH-2|SSH-2L | AMAP1|CENTB4|DDEF1|PAG2|PAP|ZG14P | |
| Cytomap | 17q11.2 | 8q24.21-q24.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase Slingshot homolog 2SSH-like protein 2 | arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating proteinADP-ribosyl | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q76I76 | Q9ULH1 | |
| Ensembl transtripts involved in fusion gene | ENST00000269033, ENST00000540801, ENST00000324677, ENST00000582084, ENST00000590153, ENST00000579954, | ENST00000357668, ENST00000518721, ENST00000520625, | |
| Fusion gene scores | * DoF score | 24 X 11 X 6=1584 | 6 X 6 X 3=108 |
| # samples | 24 | 6 | |
| ** MAII score | log2(24/1584*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SSH2 [Title/Abstract] AND ASAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A07R-01A | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000269033 | ENST00000357668 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| 5CDS-5UTR | ENST00000269033 | ENST00000518721 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| 5CDS-intron | ENST00000269033 | ENST00000520625 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| In-frame | ENST00000540801 | ENST00000357668 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| 5CDS-5UTR | ENST00000540801 | ENST00000518721 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| 5CDS-intron | ENST00000540801 | ENST00000520625 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| intron-3CDS | ENST00000324677 | ENST00000357668 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| intron-5UTR | ENST00000324677 | ENST00000518721 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| intron-intron | ENST00000324677 | ENST00000520625 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| Frame-shift | ENST00000582084 | ENST00000357668 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| 5CDS-5UTR | ENST00000582084 | ENST00000518721 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| 5CDS-intron | ENST00000582084 | ENST00000520625 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| In-frame | ENST00000590153 | ENST00000357668 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| 5CDS-5UTR | ENST00000590153 | ENST00000518721 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| 5CDS-intron | ENST00000590153 | ENST00000520625 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| In-frame | ENST00000579954 | ENST00000357668 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| 5CDS-5UTR | ENST00000579954 | ENST00000518721 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
| 5CDS-intron | ENST00000579954 | ENST00000520625 | SSH2 | chr17 | 28256956 | - | ASAP1 | chr8 | 131414216 | - |
Top |
FusionProtFeatures for SSH2_ASAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SSH2 | ASAP1 |