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Fusion gene ID: 36137 |
FusionGeneSummary for SSB_SSB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SSB_SSB | Fusion gene ID: 36137 | Hgene | Tgene | Gene symbol | SSB | SSB | Gene ID | 6741 | 6741 |
| Gene name | Sjogren syndrome antigen B | Sjogren syndrome antigen B | |
| Synonyms | LARP3|La|La/SSB | LARP3|La|La/SSB | |
| Cytomap | 2q31.1 | 2q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lupus La proteinLa ribonucleoprotein domain family, member 3SS-BSS-B/La proteinautoantigen Lala autoantigenlupus La antigensjoegren syndrome type B antigen | lupus La proteinLa ribonucleoprotein domain family, member 3SS-BSS-B/La proteinautoantigen Lala autoantigenlupus La antigensjoegren syndrome type B antigen | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | P05455 | P05455 | |
| Ensembl transtripts involved in fusion gene | ENST00000260956, ENST00000409333, | ENST00000260956, ENST00000409333, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 5=80 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SSB [Title/Abstract] AND SSB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SSB | GO:0075522 | IRES-dependent viral translational initiation | 12384597 |
| Hgene | SSB | GO:1903608 | protein localization to cytoplasmic stress granule | 24965446 |
| Tgene | SSB | GO:0075522 | IRES-dependent viral translational initiation | 12384597 |
| Tgene | SSB | GO:1903608 | protein localization to cytoplasmic stress granule | 24965446 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM968087 | SSB | chr2 | 170663549 | - | SSB | chr2 | 170667457 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000260956 | ENST00000260956 | SSB | chr2 | 170663549 | - | SSB | chr2 | 170667457 | - |
| Frame-shift | ENST00000260956 | ENST00000409333 | SSB | chr2 | 170663549 | - | SSB | chr2 | 170667457 | - |
| Frame-shift | ENST00000409333 | ENST00000260956 | SSB | chr2 | 170663549 | - | SSB | chr2 | 170667457 | - |
| Frame-shift | ENST00000409333 | ENST00000409333 | SSB | chr2 | 170663549 | - | SSB | chr2 | 170667457 | - |
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FusionProtFeatures for SSB_SSB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SSB | SSB |