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Fusion gene ID: 36051 |
FusionGeneSummary for SRRM1_AUNIP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SRRM1_AUNIP | Fusion gene ID: 36051 | Hgene | Tgene | Gene symbol | SRRM1 | AUNIP | Gene ID | 10250 | 79000 |
| Gene name | serine and arginine repetitive matrix 1 | aurora kinase A and ninein interacting protein | |
| Synonyms | 160-KD|POP101|SRM160 | AIBP|C1orf135 | |
| Cytomap | 1p36.11 | 1p36.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/arginine repetitive matrix protein 1SR-related nuclear matrix protein of 160 kDaSer/Arg-related nuclear matrix proteinserine/arginine repetitive matrix 1 | aurora kinase A and ninein-interacting proteinaurora A-binding protein | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q8IYB3 | Q9H7T9 | |
| Ensembl transtripts involved in fusion gene | ENST00000323848, ENST00000447431, ENST00000374389, ENST00000479034, ENST00000537199, | ENST00000538789, ENST00000481602, ENST00000374298, | |
| Fusion gene scores | * DoF score | 8 X 10 X 3=240 | 3 X 2 X 3=18 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SRRM1 [Title/Abstract] AND AUNIP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | AUNIP | GO:0000724 | double-strand break repair via homologous recombination | 29042561 |
| Tgene | AUNIP | GO:2001033 | negative regulation of double-strand break repair via nonhomologous end joining | 29042561 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-D8-A1XZ-01A | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000323848 | ENST00000538789 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| 5CDS-intron | ENST00000323848 | ENST00000481602 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| 5CDS-intron | ENST00000323848 | ENST00000374298 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| Frame-shift | ENST00000447431 | ENST00000538789 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| 5CDS-intron | ENST00000447431 | ENST00000481602 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| 5CDS-intron | ENST00000447431 | ENST00000374298 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| Frame-shift | ENST00000374389 | ENST00000538789 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| 5CDS-intron | ENST00000374389 | ENST00000481602 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| 5CDS-intron | ENST00000374389 | ENST00000374298 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| 3UTR-3CDS | ENST00000479034 | ENST00000538789 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| 3UTR-intron | ENST00000479034 | ENST00000481602 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| 3UTR-intron | ENST00000479034 | ENST00000374298 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| In-frame | ENST00000537199 | ENST00000538789 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| 5CDS-intron | ENST00000537199 | ENST00000481602 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
| 5CDS-intron | ENST00000537199 | ENST00000374298 | SRRM1 | chr1 | 24981620 | + | AUNIP | chr1 | 26164045 | - |
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FusionProtFeatures for SRRM1_AUNIP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SRRM1 | AUNIP |