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Fusion gene ID: 35909 |
FusionGeneSummary for SRCAP_GNB1L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SRCAP_GNB1L | Fusion gene ID: 35909 | Hgene | Tgene | Gene symbol | SRCAP | GNB1L | Gene ID | 10847 | 54584 |
| Gene name | Snf2 related CREBBP activator protein | G protein subunit beta 1 like | |
| Synonyms | DOMO1|EAF1|FLHS|SWR1 | DGCRK3|FKSG1|GY2|WDR14|WDVCF | |
| Cytomap | 16p11.2 | 22q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | helicase SRCAPSnf2-related CBP activator proteinSwi2/Snf2-related ATPase homolog, domino homolog 1domino homolog 2 | guanine nucleotide-binding protein subunit beta-like protein 1G-protein beta subunit-like proteinWD repeat-containing protein 14WD40 repeat-containing protein deleted in VCFSg protein subunit beta-like protein 1guanine nucleotide binding protein (G p | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6ZRS2 | Q9BYB4 | |
| Ensembl transtripts involved in fusion gene | ENST00000344771, ENST00000395059, ENST00000262518, | ENST00000329517, ENST00000403325, ENST00000405009, ENST00000460402, | |
| Fusion gene scores | * DoF score | 7 X 9 X 4=252 | 5 X 5 X 5=125 |
| # samples | 9 | 5 | |
| ** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SRCAP [Title/Abstract] AND GNB1L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-AP-A3K1-01A | SRCAP | chr16 | 30752028 | + | GNB1L | chr22 | 19799970 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000344771 | ENST00000329517 | SRCAP | chr16 | 30752028 | + | GNB1L | chr22 | 19799970 | - |
| intron-3CDS | ENST00000344771 | ENST00000403325 | SRCAP | chr16 | 30752028 | + | GNB1L | chr22 | 19799970 | - |
| intron-3CDS | ENST00000344771 | ENST00000405009 | SRCAP | chr16 | 30752028 | + | GNB1L | chr22 | 19799970 | - |
| intron-5UTR | ENST00000344771 | ENST00000460402 | SRCAP | chr16 | 30752028 | + | GNB1L | chr22 | 19799970 | - |
| intron-3CDS | ENST00000395059 | ENST00000329517 | SRCAP | chr16 | 30752028 | + | GNB1L | chr22 | 19799970 | - |
| intron-3CDS | ENST00000395059 | ENST00000403325 | SRCAP | chr16 | 30752028 | + | GNB1L | chr22 | 19799970 | - |
| intron-3CDS | ENST00000395059 | ENST00000405009 | SRCAP | chr16 | 30752028 | + | GNB1L | chr22 | 19799970 | - |
| intron-5UTR | ENST00000395059 | ENST00000460402 | SRCAP | chr16 | 30752028 | + | GNB1L | chr22 | 19799970 | - |
| intron-3CDS | ENST00000262518 | ENST00000329517 | SRCAP | chr16 | 30752028 | + | GNB1L | chr22 | 19799970 | - |
| intron-3CDS | ENST00000262518 | ENST00000403325 | SRCAP | chr16 | 30752028 | + | GNB1L | chr22 | 19799970 | - |
| intron-3CDS | ENST00000262518 | ENST00000405009 | SRCAP | chr16 | 30752028 | + | GNB1L | chr22 | 19799970 | - |
| intron-5UTR | ENST00000262518 | ENST00000460402 | SRCAP | chr16 | 30752028 | + | GNB1L | chr22 | 19799970 | - |
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FusionProtFeatures for SRCAP_GNB1L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SRCAP | GNB1L |