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Fusion gene ID: 35895

FusionGeneSummary for SQSTM1_NTRK2

Fusion gene summary

Fusion gene information	Fusion gene name: SQSTM1_NTRK2
	Fusion gene ID: 35895
		Hgene	Tgene
	Gene symbol	SQSTM1	NTRK2
	Gene ID	8878	4915
	Gene name	sequestosome 1	neurotrophic receptor tyrosine kinase 2
	Synonyms	A170\|DMRV\|FTDALS3\|NADGP\|OSIL\|PDB3\|ZIP3\|p60\|p62\|p62B	EIEE58\|GP145-TrkB\|OBHD\|TRKB\|trk-B
	Cytomap	5q35.3	9q21.33
	Type of gene	protein-coding	protein-coding
	Description	sequestosome-1EBI3-associated protein of 60 kDaEBI3-associated protein p60EBIAPoxidative stress induced likephosphotyrosine independent ligand for the Lck SH2 domain p62phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDaubiquitin-bi	BDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B
	Modification date	20180523	20180523
	UniProtAcc	Q13501	Q16620
	Ensembl transtripts involved in fusion gene	ENST00000376929, ENST00000506690, ENST00000389805, ENST00000402874, ENST00000510187, ENST00000360718,	ENST00000376214, ENST00000376213, ENST00000395882, ENST00000304053, ENST00000376208, ENST00000277120, ENST00000323115, ENST00000359847, ENST00000395866,
Fusion gene scores	* DoF score	17 X 18 X 7=2142	5 X 4 X 4=80
	# samples	21	5
	** MAII score	log2(21/2142*10)=-3.35049724708413 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SQSTM1 [Title/Abstract] AND NTRK2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Kinase involved fusion gene, inframe and retained kinase domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SQSTM1	GO:0007032	endosome organization	27368102
Hgene	SQSTM1	GO:0061635	regulation of protein complex stability	25127057
Hgene	SQSTM1	GO:1905719	protein localization to perinuclear region of cytoplasm	27368102

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LGG	TCGA-DU-A76L-01A	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000376929	ENST00000376214	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
In-frame	ENST00000376929	ENST00000376213	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000376929	ENST00000395882	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000376929	ENST00000304053	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000376929	ENST00000376208	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000376929	ENST00000277120	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000376929	ENST00000323115	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000376929	ENST00000359847	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000376929	ENST00000395866	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
intron-3CDS	ENST00000506690	ENST00000376214	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
intron-3CDS	ENST00000506690	ENST00000376213	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
intron-intron	ENST00000506690	ENST00000395882	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
intron-intron	ENST00000506690	ENST00000304053	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
intron-intron	ENST00000506690	ENST00000376208	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
intron-intron	ENST00000506690	ENST00000277120	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
intron-intron	ENST00000506690	ENST00000323115	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
intron-intron	ENST00000506690	ENST00000359847	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
intron-intron	ENST00000506690	ENST00000395866	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
In-frame	ENST00000389805	ENST00000376214	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
In-frame	ENST00000389805	ENST00000376213	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000389805	ENST00000395882	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000389805	ENST00000304053	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000389805	ENST00000376208	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000389805	ENST00000277120	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000389805	ENST00000323115	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000389805	ENST00000359847	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000389805	ENST00000395866	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
In-frame	ENST00000402874	ENST00000376214	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
In-frame	ENST00000402874	ENST00000376213	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000402874	ENST00000395882	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000402874	ENST00000304053	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000402874	ENST00000376208	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000402874	ENST00000277120	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000402874	ENST00000323115	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000402874	ENST00000359847	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000402874	ENST00000395866	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
In-frame	ENST00000510187	ENST00000376214	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
In-frame	ENST00000510187	ENST00000376213	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000510187	ENST00000395882	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000510187	ENST00000304053	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000510187	ENST00000376208	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000510187	ENST00000277120	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000510187	ENST00000323115	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000510187	ENST00000359847	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000510187	ENST00000395866	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
In-frame	ENST00000360718	ENST00000376214	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
In-frame	ENST00000360718	ENST00000376213	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000360718	ENST00000395882	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000360718	ENST00000304053	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000360718	ENST00000376208	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000360718	ENST00000277120	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000360718	ENST00000323115	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000360718	ENST00000359847	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+
5CDS-intron	ENST00000360718	ENST00000395866	SQSTM1	chr5	179252226	+	NTRK2	chr9	87549077	+

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FusionProtFeatures for SQSTM1_NTRK2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SQSTM1 Q13501	NTRK2 Q16620

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Fusion gene ID: 35895

FusionGeneSummary for SQSTM1_NTRK2

FusionProtFeatures for SQSTM1_NTRK2