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Fusion gene ID: 35868 |
FusionGeneSummary for SPTBN5_MGA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPTBN5_MGA | Fusion gene ID: 35868 | Hgene | Tgene | Gene symbol | SPTBN5 | MGA | Gene ID | 51332 | 23269 |
| Gene name | spectrin beta, non-erythrocytic 5 | MGA, MAX dimerization protein | |
| Synonyms | BSPECV|HUBSPECV|HUSPECV | MAD5|MXD5 | |
| Cytomap | 15q15.1 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | spectrin beta chain, non-erythrocytic 5beta V spectrinspectrin beta chain, brain 4spectrin, non-erythroid beta chain 4 | MAX gene-associated proteinMAX dimerization protein 5 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9NRC6 | Q8IWI9 | |
| Ensembl transtripts involved in fusion gene | ENST00000320955, | ENST00000568630, ENST00000545763, ENST00000389936, ENST00000219905, ENST00000566586, ENST00000570161, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 3=27 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SPTBN5 [Title/Abstract] AND MGA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SPTBN5 | GO:0051260 | protein homooligomerization | 23704327 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-85-8479-01A | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000320955 | ENST00000568630 | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
| 5CDS-intron | ENST00000320955 | ENST00000545763 | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
| 5CDS-intron | ENST00000320955 | ENST00000389936 | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
| 5CDS-intron | ENST00000320955 | ENST00000219905 | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
| 5CDS-intron | ENST00000320955 | ENST00000566586 | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
| 5CDS-intron | ENST00000320955 | ENST00000570161 | SPTBN5 | chr15 | 42153617 | - | MGA | chr15 | 42053937 | + |
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FusionProtFeatures for SPTBN5_MGA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPTBN5 | MGA |