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Fusion gene ID: 358 |
FusionGeneSummary for ACAT2_ACAT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACAT2_ACAT2 | Fusion gene ID: 358 | Hgene | Tgene | Gene symbol | ACAT2 | ACAT2 | Gene ID | 8435 | 8435 |
| Gene name | sterol O-acyltransferase 2 | sterol O-acyltransferase 2 | |
| Synonyms | ACACT2|ACAT2|ARGP2 | ACACT2|ACAT2|ARGP2 | |
| Cytomap | 12q13.13 | 12q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sterol O-acyltransferase 2ACAT-2acyl Co-A: cholesterol acyltransferase 2acyl coenzyme A:cholesterol acyltransferase 2acyl-CoA:cholesterol acyltransferase 2cholesterol acyltransferase 2 | sterol O-acyltransferase 2ACAT-2acyl Co-A: cholesterol acyltransferase 2acyl coenzyme A:cholesterol acyltransferase 2acyl-CoA:cholesterol acyltransferase 2cholesterol acyltransferase 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BWD1 | Q9BWD1 | |
| Ensembl transtripts involved in fusion gene | ENST00000367048, ENST00000541436, ENST00000472052, | ENST00000367048, ENST00000541436, ENST00000472052, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: ACAT2 [Title/Abstract] AND ACAT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACAT2 | GO:0008203 | cholesterol metabolic process | 16647063 |
| Hgene | ACAT2 | GO:0034435 | cholesterol esterification | 16647063 |
| Tgene | ACAT2 | GO:0008203 | cholesterol metabolic process | 16647063 |
| Tgene | ACAT2 | GO:0034435 | cholesterol esterification | 16647063 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG766524 | ACAT2 | chr6 | 160199294 | + | ACAT2 | chr6 | 160199703 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000367048 | ENST00000367048 | ACAT2 | chr6 | 160199294 | + | ACAT2 | chr6 | 160199703 | - |
| Frame-shift | ENST00000367048 | ENST00000541436 | ACAT2 | chr6 | 160199294 | + | ACAT2 | chr6 | 160199703 | - |
| 5CDS-3UTR | ENST00000367048 | ENST00000472052 | ACAT2 | chr6 | 160199294 | + | ACAT2 | chr6 | 160199703 | - |
| Frame-shift | ENST00000541436 | ENST00000367048 | ACAT2 | chr6 | 160199294 | + | ACAT2 | chr6 | 160199703 | - |
| Frame-shift | ENST00000541436 | ENST00000541436 | ACAT2 | chr6 | 160199294 | + | ACAT2 | chr6 | 160199703 | - |
| 5CDS-3UTR | ENST00000541436 | ENST00000472052 | ACAT2 | chr6 | 160199294 | + | ACAT2 | chr6 | 160199703 | - |
| 3UTR-3CDS | ENST00000472052 | ENST00000367048 | ACAT2 | chr6 | 160199294 | + | ACAT2 | chr6 | 160199703 | - |
| 3UTR-3CDS | ENST00000472052 | ENST00000541436 | ACAT2 | chr6 | 160199294 | + | ACAT2 | chr6 | 160199703 | - |
| 3UTR-3UTR | ENST00000472052 | ENST00000472052 | ACAT2 | chr6 | 160199294 | + | ACAT2 | chr6 | 160199703 | - |
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FusionProtFeatures for ACAT2_ACAT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACAT2 | ACAT2 |