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Fusion gene ID: 35667 |
FusionGeneSummary for SPG7_MALAT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPG7_MALAT1 | Fusion gene ID: 35667 | Hgene | Tgene | Gene symbol | SPG7 | MALAT1 | Gene ID | 6687 | 378938 |
| Gene name | SPG7, paraplegin matrix AAA peptidase subunit | metastasis associated lung adenocarcinoma transcript 1 | |
| Synonyms | CAR|CMAR|PGN|SPG5C | HCN|LINC00047|NCRNA00047|NEAT2|PRO2853 | |
| Cytomap | 16q24.3 | 11q13.1 | |
| Type of gene | protein-coding | ncRNA | |
| Description | paraplegincell matrix adhesion regulatorspastic paraplegia 7 (pure and complicated autosomal recessive)spastic paraplegia 7 protein | hepcarcinlong intergenic non-protein coding RNA 47metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)nuclear enriched abundant transcript 2nuclear paraspeckle assembly transcript 2 (non-protein coding) | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9UQ90 | ||
| Ensembl transtripts involved in fusion gene | ENST00000268704, ENST00000341316, ENST00000565891, | ENST00000534336, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 71 X 110 X 1=7810 |
| # samples | 5 | 126 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(126/7810*10)=-2.63189881464206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SPG7 [Title/Abstract] AND MALAT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA574455 | SPG7 | chr16 | 89586265 | - | MALAT1 | chr11 | 65266526 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000268704 | ENST00000534336 | SPG7 | chr16 | 89586265 | - | MALAT1 | chr11 | 65266526 | + |
| intron-3UTR | ENST00000341316 | ENST00000534336 | SPG7 | chr16 | 89586265 | - | MALAT1 | chr11 | 65266526 | + |
| intron-3UTR | ENST00000565891 | ENST00000534336 | SPG7 | chr16 | 89586265 | - | MALAT1 | chr11 | 65266526 | + |
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FusionProtFeatures for SPG7_MALAT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPG7 | MALAT1 |