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Fusion gene ID: 35610 |
FusionGeneSummary for SPDEF_VSTM2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPDEF_VSTM2B | Fusion gene ID: 35610 | Hgene | Tgene | Gene symbol | SPDEF | VSTM2B | Gene ID | 25803 | 342865 |
| Gene name | SAM pointed domain containing ETS transcription factor | V-set and transmembrane domain containing 2B | |
| Synonyms | PDEF|bA375E1.3 | - | |
| Cytomap | 6p21.31 | 19q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SAM pointed domain-containing Ets transcription factorprostate epithelium-specific Ets transcription factorprostate-derived Ets factorprostate-specific Ets | V-set and transmembrane domain-containing protein 2B | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | O95238 | A6NLU5 | |
| Ensembl transtripts involved in fusion gene | ENST00000374037, ENST00000544425, | ENST00000335523, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 8 X 2 X 6=96 |
| # samples | 2 | 7 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SPDEF [Title/Abstract] AND VSTM2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SPDEF | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21656828 |
| Hgene | SPDEF | GO:0043065 | positive regulation of apoptotic process | 21656828 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-55-7913-01B | SPDEF | chr6 | 34523706 | - | VSTM2B | chr19 | 30054753 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000374037 | ENST00000335523 | SPDEF | chr6 | 34523706 | - | VSTM2B | chr19 | 30054753 | + |
| 5UTR-3CDS | ENST00000544425 | ENST00000335523 | SPDEF | chr6 | 34523706 | - | VSTM2B | chr19 | 30054753 | + |
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FusionProtFeatures for SPDEF_VSTM2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPDEF | VSTM2B |