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Fusion gene ID: 35608 |
FusionGeneSummary for SPCS3_VEGFC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPCS3_VEGFC | Fusion gene ID: 35608 | Hgene | Tgene | Gene symbol | SPCS3 | VEGFC | Gene ID | 60559 | 7424 |
| Gene name | signal peptidase complex subunit 3 | vascular endothelial growth factor C | |
| Synonyms | PRO3567|SPC22/23|SPC3|YLR066W | Flt4-L|LMPH1D|VRP | |
| Cytomap | 4q34.2 | 4q34.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | signal peptidase complex subunit 3SPase 22 kDa subunitSPase 22/23 kDa subunitmicrosomal signal peptidase 22/23 kDa subunitmicrosomal signal peptidase 23 kDa subunitsignal peptidase complex subunit 3 homolog | vascular endothelial growth factor CFLT4 ligand DHMvascular endothelial growth factor-related protein | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P61009 | P49767 | |
| Ensembl transtripts involved in fusion gene | ENST00000503362, ENST00000507001, | ENST00000280193, ENST00000507638, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 2 X 3=18 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SPCS3 [Title/Abstract] AND VEGFC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SPCS3 | GO:0006508 | proteolysis | 27499293 |
| Tgene | VEGFC | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 23878260 |
| Tgene | VEGFC | GO:0050930 | induction of positive chemotaxis | 19275959 |
| Tgene | VEGFC | GO:0060754 | positive regulation of mast cell chemotaxis | 19275959 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-KP-A3W3-01A | SPCS3 | chr4 | 177241370 | + | VEGFC | chr4 | 177650900 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000503362 | ENST00000280193 | SPCS3 | chr4 | 177241370 | + | VEGFC | chr4 | 177650900 | - |
| 5CDS-intron | ENST00000503362 | ENST00000507638 | SPCS3 | chr4 | 177241370 | + | VEGFC | chr4 | 177650900 | - |
| intron-3CDS | ENST00000507001 | ENST00000280193 | SPCS3 | chr4 | 177241370 | + | VEGFC | chr4 | 177650900 | - |
| intron-intron | ENST00000507001 | ENST00000507638 | SPCS3 | chr4 | 177241370 | + | VEGFC | chr4 | 177650900 | - |
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FusionProtFeatures for SPCS3_VEGFC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPCS3 | VEGFC |