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Fusion gene ID: 35558 |
FusionGeneSummary for SPARC_NPLOC4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPARC_NPLOC4 | Fusion gene ID: 35558 | Hgene | Tgene | Gene symbol | SPARC | NPLOC4 | Gene ID | 6678 | 55666 |
| Gene name | secreted protein acidic and cysteine rich | NPL4 homolog, ubiquitin recognition factor | |
| Synonyms | BM-40|OI17|ON | NPL4 | |
| Cytomap | 5q33.1 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SPARCbasement-membrane protein 40secreted protein, acidic, cysteine-rich (osteonectin) | nuclear protein localization protein 4 homologNPLOC4 ubiquitin recognition factornuclear protein localization 4 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P09486 | Q8TAT6 | |
| Ensembl transtripts involved in fusion gene | ENST00000231061, ENST00000537849, | ENST00000331134, ENST00000374747, ENST00000539314, ENST00000572760, ENST00000573876, ENST00000574344, | |
| Fusion gene scores | * DoF score | 12 X 16 X 5=960 | 9 X 7 X 8=504 |
| # samples | 18 | 11 | |
| ** MAII score | log2(18/960*10)=-2.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/504*10)=-2.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SPARC [Title/Abstract] AND NPLOC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SPARC | GO:0001937 | negative regulation of endothelial cell proliferation | 12867428 |
| Hgene | SPARC | GO:0010595 | positive regulation of endothelial cell migration | 12867428 |
| Hgene | SPARC | GO:0016525 | negative regulation of angiogenesis | 12867428 |
| Hgene | SPARC | GO:0022604 | regulation of cell morphogenesis | 15389586 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA426012 | SPARC | chr5 | 151042127 | + | NPLOC4 | chr17 | 79524285 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000231061 | ENST00000331134 | SPARC | chr5 | 151042127 | + | NPLOC4 | chr17 | 79524285 | + |
| intron-intron | ENST00000231061 | ENST00000374747 | SPARC | chr5 | 151042127 | + | NPLOC4 | chr17 | 79524285 | + |
| intron-intron | ENST00000231061 | ENST00000539314 | SPARC | chr5 | 151042127 | + | NPLOC4 | chr17 | 79524285 | + |
| intron-intron | ENST00000231061 | ENST00000572760 | SPARC | chr5 | 151042127 | + | NPLOC4 | chr17 | 79524285 | + |
| intron-intron | ENST00000231061 | ENST00000573876 | SPARC | chr5 | 151042127 | + | NPLOC4 | chr17 | 79524285 | + |
| intron-intron | ENST00000231061 | ENST00000574344 | SPARC | chr5 | 151042127 | + | NPLOC4 | chr17 | 79524285 | + |
| intron-3UTR | ENST00000537849 | ENST00000331134 | SPARC | chr5 | 151042127 | + | NPLOC4 | chr17 | 79524285 | + |
| intron-intron | ENST00000537849 | ENST00000374747 | SPARC | chr5 | 151042127 | + | NPLOC4 | chr17 | 79524285 | + |
| intron-intron | ENST00000537849 | ENST00000539314 | SPARC | chr5 | 151042127 | + | NPLOC4 | chr17 | 79524285 | + |
| intron-intron | ENST00000537849 | ENST00000572760 | SPARC | chr5 | 151042127 | + | NPLOC4 | chr17 | 79524285 | + |
| intron-intron | ENST00000537849 | ENST00000573876 | SPARC | chr5 | 151042127 | + | NPLOC4 | chr17 | 79524285 | + |
| intron-intron | ENST00000537849 | ENST00000574344 | SPARC | chr5 | 151042127 | + | NPLOC4 | chr17 | 79524285 | + |
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FusionProtFeatures for SPARC_NPLOC4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPARC | NPLOC4 |