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Fusion gene ID: 35542 |
FusionGeneSummary for SPAG9_UBBP4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPAG9_UBBP4 | Fusion gene ID: 35542 | Hgene | Tgene | Gene symbol | SPAG9 | UBBP4 | Gene ID | 9043 | 23666 |
| Gene name | sperm associated antigen 9 | ubiquitin B pseudogene 4 | |
| Synonyms | CT89|HLC-6|HLC4|HLC6|JIP-4|JIP4|JLP|PHET|PIG6 | - | |
| Cytomap | 17q21.33 | 17p11.2 | |
| Type of gene | protein-coding | pseudo | |
| Description | C-Jun-amino-terminal kinase-interacting protein 4JNK interacting proteinJNK/SAPK-associated proteinMax-binding proteinc-Jun NH2-terminal kinase-associated leucine zipper proteincancer/testis antigen 89human lung cancer oncogene 6 proteinlung cancer | - | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O60271 | ||
| Ensembl transtripts involved in fusion gene | ENST00000262013, ENST00000505279, ENST00000357122, ENST00000509724, ENST00000510283, | ENST00000584755, ENST00000583708, ENST00000584398, ENST00000578713, | |
| Fusion gene scores | * DoF score | 15 X 11 X 9=1485 | 3 X 1 X 3=9 |
| # samples | 16 | 3 | |
| ** MAII score | log2(16/1485*10)=-3.21431912080077 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SPAG9 [Title/Abstract] AND UBBP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SPAG9 | GO:0042147 | retrograde transport, endosome to Golgi | 19056739 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-FV-A2QR-01A | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000262013 | ENST00000584755 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| 5CDS-5UTR | ENST00000262013 | ENST00000583708 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| 5CDS-5UTR | ENST00000262013 | ENST00000584398 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| 5CDS-5UTR | ENST00000262013 | ENST00000578713 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| 5CDS-5UTR | ENST00000505279 | ENST00000584755 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| 5CDS-5UTR | ENST00000505279 | ENST00000583708 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| 5CDS-5UTR | ENST00000505279 | ENST00000584398 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| 5CDS-5UTR | ENST00000505279 | ENST00000578713 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| 5CDS-5UTR | ENST00000357122 | ENST00000584755 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| 5CDS-5UTR | ENST00000357122 | ENST00000583708 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| 5CDS-5UTR | ENST00000357122 | ENST00000584398 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| 5CDS-5UTR | ENST00000357122 | ENST00000578713 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| intron-5UTR | ENST00000509724 | ENST00000584755 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| intron-5UTR | ENST00000509724 | ENST00000583708 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| intron-5UTR | ENST00000509724 | ENST00000584398 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| intron-5UTR | ENST00000509724 | ENST00000578713 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| intron-5UTR | ENST00000510283 | ENST00000584755 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| intron-5UTR | ENST00000510283 | ENST00000583708 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| intron-5UTR | ENST00000510283 | ENST00000584398 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
| intron-5UTR | ENST00000510283 | ENST00000578713 | SPAG9 | chr17 | 49156945 | - | UBBP4 | chr17 | 21730693 | + |
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FusionProtFeatures for SPAG9_UBBP4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPAG9 | UBBP4 |