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Fusion gene ID: 35513 |
FusionGeneSummary for SPAG1_ANGPT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPAG1_ANGPT1 | Fusion gene ID: 35513 | Hgene | Tgene | Gene symbol | SPAG1 | ANGPT1 | Gene ID | 6674 | 284 |
| Gene name | sperm associated antigen 1 | angiopoietin 1 | |
| Synonyms | CILD28|CT140|HEL-S-268|HSD-3.8|SP75|TPIS | AGP1|AGPT|ANG1 | |
| Cytomap | 8q22.2 | 8q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sperm-associated antigen 1TPR-containing protein involved in spermatogenesisepididymis secretory protein Li 268infertility-related sperm protein Spag-1tetratricopeptide repeat-containing protein | angiopoietin-1ANG-1 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q07617 | Q15389 | |
| Ensembl transtripts involved in fusion gene | ENST00000520643, ENST00000251809, ENST00000520508, ENST00000388798, ENST00000523302, | ENST00000520052, ENST00000520734, ENST00000518386, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 7 X 4 X 6=168 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SPAG1 [Title/Abstract] AND ANGPT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ANGPT1 | GO:0001936 | regulation of endothelial cell proliferation | 8980223 |
| Tgene | ANGPT1 | GO:0002040 | sprouting angiogenesis | 9560344|10218485 |
| Tgene | ANGPT1 | GO:0002092 | positive regulation of receptor internalization | 19424712 |
| Tgene | ANGPT1 | GO:0007162 | negative regulation of cell adhesion | 19674970 |
| Tgene | ANGPT1 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | 19424712 |
| Tgene | ANGPT1 | GO:0010595 | positive regulation of endothelial cell migration | 12958144 |
| Tgene | ANGPT1 | GO:0014842 | regulation of skeletal muscle satellite cell proliferation | 19733541 |
| Tgene | ANGPT1 | GO:0030210 | heparin biosynthetic process | 19297368 |
| Tgene | ANGPT1 | GO:0031398 | positive regulation of protein ubiquitination | 19689429 |
| Tgene | ANGPT1 | GO:0034394 | protein localization to cell surface | 19615361 |
| Tgene | ANGPT1 | GO:0043066 | negative regulation of apoptotic process | 10218485|12958144 |
| Tgene | ANGPT1 | GO:0043116 | negative regulation of vascular permeability | 14978158|19297368 |
| Tgene | ANGPT1 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 9660821 |
| Tgene | ANGPT1 | GO:0048014 | Tie signaling pathway | 19689429|19922791 |
| Tgene | ANGPT1 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 15851516|19689429 |
| Tgene | ANGPT1 | GO:0050918 | positive chemotaxis | 9660821 |
| Tgene | ANGPT1 | GO:0051897 | positive regulation of protein kinase B signaling | 18425120|19615361 |
| Tgene | ANGPT1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 18425120|19615361 |
| Tgene | ANGPT1 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 19674970 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-AB2Z-01A | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000520643 | ENST00000520052 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| intron-intron | ENST00000520643 | ENST00000520734 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| intron-intron | ENST00000520643 | ENST00000518386 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| 5CDS-intron | ENST00000251809 | ENST00000520052 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| 5CDS-intron | ENST00000251809 | ENST00000520734 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| 5CDS-intron | ENST00000251809 | ENST00000518386 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| intron-intron | ENST00000520508 | ENST00000520052 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| intron-intron | ENST00000520508 | ENST00000520734 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| intron-intron | ENST00000520508 | ENST00000518386 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| 5CDS-intron | ENST00000388798 | ENST00000520052 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| 5CDS-intron | ENST00000388798 | ENST00000520734 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| 5CDS-intron | ENST00000388798 | ENST00000518386 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| intron-intron | ENST00000523302 | ENST00000520052 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| intron-intron | ENST00000523302 | ENST00000520734 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
| intron-intron | ENST00000523302 | ENST00000518386 | SPAG1 | chr8 | 101245765 | + | ANGPT1 | chr8 | 108359325 | - |
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FusionProtFeatures for SPAG1_ANGPT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPAG1 | ANGPT1 |