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Fusion gene ID: 35439

FusionGeneSummary for SOX13_PPFIA4

Fusion gene summary

Fusion gene information	Fusion gene name: SOX13_PPFIA4
	Fusion gene ID: 35439
		Hgene	Tgene
	Gene symbol	SOX13	PPFIA4
	Gene ID	9580	8497
	Gene name	SRY-box 13	PTPRF interacting protein alpha 4
	Synonyms	ICA12\|Sox-13	-
	Cytomap	1q32.1	1q32.1
	Type of gene	protein-coding	protein-coding
	Description	transcription factor SOX-13SRY (sex determining region Y)-box 13SRY-related HMG-box gene 13islet cell antibody 12islet cell antigen 12type 1 diabetes autoantigen ICA12	liprin-alpha-4protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
	Modification date	20180523	20180522
	UniProtAcc	Q9UN79	O75335
	Ensembl transtripts involved in fusion gene	ENST00000367203, ENST00000367204,	ENST00000367240, ENST00000295706, ENST00000447715, ENST00000414050, ENST00000272198, ENST00000599966, ENST00000594572,
Fusion gene scores	* DoF score	4 X 3 X 3=36	2 X 2 X 2=8
	# samples	4	2
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(2/8*10)=1.32192809488736
Context	PubMed: SOX13 [Title/Abstract] AND PPFIA4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	UCS	TCGA-N8-A4PQ-01A	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000367203	ENST00000367240	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+
3UTR-3CDS	ENST00000367203	ENST00000295706	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+
3UTR-intron	ENST00000367203	ENST00000447715	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+
3UTR-intron	ENST00000367203	ENST00000414050	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+
3UTR-intron	ENST00000367203	ENST00000272198	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+
3UTR-intron	ENST00000367203	ENST00000599966	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+
3UTR-intron	ENST00000367203	ENST00000594572	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+
5UTR-3CDS	ENST00000367204	ENST00000367240	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+
5UTR-3CDS	ENST00000367204	ENST00000295706	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+
5UTR-intron	ENST00000367204	ENST00000447715	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+
5UTR-intron	ENST00000367204	ENST00000414050	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+
5UTR-intron	ENST00000367204	ENST00000272198	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+
5UTR-intron	ENST00000367204	ENST00000599966	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+
5UTR-intron	ENST00000367204	ENST00000594572	SOX13	chr1	204042839	+	PPFIA4	chr1	203022881	+

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FusionProtFeatures for SOX13_PPFIA4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SOX13 Q9UN79	PPFIA4 O75335

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Fusion gene ID: 35439

FusionGeneSummary for SOX13_PPFIA4

FusionProtFeatures for SOX13_PPFIA4