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Fusion gene ID: 35429 |
FusionGeneSummary for SOS2_POLN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SOS2_POLN | Fusion gene ID: 35429 | Hgene | Tgene | Gene symbol | SOS2 | POLN | Gene ID | 6655 | 353497 |
| Gene name | SOS Ras/Rho guanine nucleotide exchange factor 2 | DNA polymerase nu | |
| Synonyms | NS9|SOS-2 | POL4P | |
| Cytomap | 14q21.3 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | son of sevenless homolog 2guanine nucleotide releasing factor | DNA polymerase nuDNA polymerase NDNA polymerase POL4Ppolymerase (DNA directed) nupolymerase (DNA) nu | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q07890 | Q7Z5Q5 | |
| Ensembl transtripts involved in fusion gene | ENST00000216373, ENST00000543680, ENST00000555794, | ENST00000382865, ENST00000511885, ENST00000515357, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 12 X 7 X 9=756 |
| # samples | 6 | 12 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/756*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SOS2 [Title/Abstract] AND POLN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | POLN | GO:0019985 | translesion synthesis | 20102227 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCS | TCGA-NA-A5I1-01A | SOS2 | chr14 | 50697915 | - | POLN | chr4 | 2176478 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000216373 | ENST00000382865 | SOS2 | chr14 | 50697915 | - | POLN | chr4 | 2176478 | - |
| In-frame | ENST00000216373 | ENST00000511885 | SOS2 | chr14 | 50697915 | - | POLN | chr4 | 2176478 | - |
| 5CDS-5UTR | ENST00000216373 | ENST00000515357 | SOS2 | chr14 | 50697915 | - | POLN | chr4 | 2176478 | - |
| In-frame | ENST00000543680 | ENST00000382865 | SOS2 | chr14 | 50697915 | - | POLN | chr4 | 2176478 | - |
| In-frame | ENST00000543680 | ENST00000511885 | SOS2 | chr14 | 50697915 | - | POLN | chr4 | 2176478 | - |
| 5CDS-5UTR | ENST00000543680 | ENST00000515357 | SOS2 | chr14 | 50697915 | - | POLN | chr4 | 2176478 | - |
| intron-3CDS | ENST00000555794 | ENST00000382865 | SOS2 | chr14 | 50697915 | - | POLN | chr4 | 2176478 | - |
| intron-3CDS | ENST00000555794 | ENST00000511885 | SOS2 | chr14 | 50697915 | - | POLN | chr4 | 2176478 | - |
| intron-5UTR | ENST00000555794 | ENST00000515357 | SOS2 | chr14 | 50697915 | - | POLN | chr4 | 2176478 | - |
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FusionProtFeatures for SOS2_POLN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SOS2 | POLN |