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Fusion gene ID: 35419 |
FusionGeneSummary for SORT1_FAF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SORT1_FAF1 | Fusion gene ID: 35419 | Hgene | Tgene | Gene symbol | SORT1 | FAF1 | Gene ID | 6272 | 11124 |
| Gene name | sortilin 1 | Fas associated factor 1 | |
| Synonyms | Gp95|LDLCQ6|NT3|NTR3 | CGI-03|HFAF1s|UBXD12|UBXN3A|hFAF1 | |
| Cytomap | 1p13.3|1p21.3-p13.1 | 1p32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sortilin100 kDa NT receptorglycoprotein 95neurotensin receptor 3 | FAS-associated factor 1Fas (TNFRSF6) associated factor 1TNFRSF6-associated factor 1UBX domain protein 3AUBX domain-containing protein 12UBX domain-containing protein 3A | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q99523 | Q9UNN5 | |
| Ensembl transtripts involved in fusion gene | ENST00000256637, ENST00000538502, ENST00000482236, | ENST00000396153, ENST00000371778, ENST00000545823, ENST00000472808, | |
| Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 17 X 15 X 9=2295 |
| # samples | 6 | 22 | |
| ** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/2295*10)=-3.38291872477651 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SORT1 [Title/Abstract] AND FAF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SORT1 | GO:0006895 | Golgi to endosome transport | 11331584 |
| Hgene | SORT1 | GO:0006897 | endocytosis | 11331584 |
| Hgene | SORT1 | GO:0007218 | neuropeptide signaling pathway | 9756851 |
| Hgene | SORT1 | GO:0008333 | endosome to lysosome transport | 11331584 |
| Hgene | SORT1 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | 14985763 |
| Hgene | SORT1 | GO:0016050 | vesicle organization | 15992544 |
| Hgene | SORT1 | GO:0032509 | endosome transport via multivesicular body sorting pathway | 11331584 |
| Hgene | SORT1 | GO:0048227 | plasma membrane to endosome transport | 11331584 |
| Hgene | SORT1 | GO:0051005 | negative regulation of lipoprotein lipase activity | 10085125 |
| Tgene | FAF1 | GO:0010942 | positive regulation of cell death | 15596450 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DB467995 | SORT1 | chr1 | 109935649 | - | FAF1 | chr1 | 51061890 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000256637 | ENST00000396153 | SORT1 | chr1 | 109935649 | - | FAF1 | chr1 | 51061890 | - |
| intron-3CDS | ENST00000256637 | ENST00000371778 | SORT1 | chr1 | 109935649 | - | FAF1 | chr1 | 51061890 | - |
| intron-3CDS | ENST00000256637 | ENST00000545823 | SORT1 | chr1 | 109935649 | - | FAF1 | chr1 | 51061890 | - |
| intron-5UTR | ENST00000256637 | ENST00000472808 | SORT1 | chr1 | 109935649 | - | FAF1 | chr1 | 51061890 | - |
| 5UTR-3CDS | ENST00000538502 | ENST00000396153 | SORT1 | chr1 | 109935649 | - | FAF1 | chr1 | 51061890 | - |
| 5UTR-3CDS | ENST00000538502 | ENST00000371778 | SORT1 | chr1 | 109935649 | - | FAF1 | chr1 | 51061890 | - |
| 5UTR-3CDS | ENST00000538502 | ENST00000545823 | SORT1 | chr1 | 109935649 | - | FAF1 | chr1 | 51061890 | - |
| 5UTR-5UTR | ENST00000538502 | ENST00000472808 | SORT1 | chr1 | 109935649 | - | FAF1 | chr1 | 51061890 | - |
| 5UTR-3CDS | ENST00000482236 | ENST00000396153 | SORT1 | chr1 | 109935649 | - | FAF1 | chr1 | 51061890 | - |
| 5UTR-3CDS | ENST00000482236 | ENST00000371778 | SORT1 | chr1 | 109935649 | - | FAF1 | chr1 | 51061890 | - |
| 5UTR-3CDS | ENST00000482236 | ENST00000545823 | SORT1 | chr1 | 109935649 | - | FAF1 | chr1 | 51061890 | - |
| 5UTR-5UTR | ENST00000482236 | ENST00000472808 | SORT1 | chr1 | 109935649 | - | FAF1 | chr1 | 51061890 | - |
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FusionProtFeatures for SORT1_FAF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SORT1 | FAF1 |