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Fusion gene ID: 35400 |
FusionGeneSummary for SORCS3_REC8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SORCS3_REC8 | Fusion gene ID: 35400 | Hgene | Tgene | Gene symbol | SORCS3 | REC8 | Gene ID | 22986 | 9985 |
| Gene name | sortilin related VPS10 domain containing receptor 3 | REC8 meiotic recombination protein | |
| Synonyms | SORCS | HR21spB|REC8L1|Rec8p | |
| Cytomap | 10q25.1 | 14q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | VPS10 domain-containing receptor SorCS3VPS10 domain receptor protein SORCS 3 (SORCS3) | meiotic recombination protein REC8 homologREC8 homologREC8-like 1cohesin Rec8pcohesion rec8phuman homolog of rad21, S. pombekleisin-alphameiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p familymeiotic recombination p | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9UPU3 | O95072 | |
| Ensembl transtripts involved in fusion gene | ENST00000369701, ENST00000369699, | ENST00000311457, ENST00000559919, ENST00000559939, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SORCS3 [Title/Abstract] AND REC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | T07523 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000369701 | ENST00000311457 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
| intron-intron | ENST00000369701 | ENST00000559919 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
| intron-intron | ENST00000369701 | ENST00000559939 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
| intron-intron | ENST00000369699 | ENST00000311457 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
| intron-intron | ENST00000369699 | ENST00000559919 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
| intron-intron | ENST00000369699 | ENST00000559939 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
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FusionProtFeatures for SORCS3_REC8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SORCS3 | REC8 |