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Fusion gene ID: 35375 |
FusionGeneSummary for SON_XPC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SON_XPC | Fusion gene ID: 35375 | Hgene | Tgene | Gene symbol | SON | XPC | Gene ID | 6651 | 7508 |
| Gene name | SON DNA binding protein | XPC complex subunit, DNA damage recognition and repair factor | |
| Synonyms | BASS1|C21orf50|DBP-5|NREBP|SON3|TOKIMS | RAD4|XP3|XPCC|p125 | |
| Cytomap | 21q22.11 | 3p25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein SONBax antagonist selected in Saccharomyces 1NRE-binding proteinnegative regulatory element-binding protein | DNA repair protein complementing XP-C cellsmutant xeroderma pigmentosum group Cxeroderma pigmentosum, complementation group C | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P18583 | Q01831 | |
| Ensembl transtripts involved in fusion gene | ENST00000356577, ENST00000290239, ENST00000381692, ENST00000300278, ENST00000381679, ENST00000470533, | ENST00000285021, ENST00000449060, | |
| Fusion gene scores | * DoF score | 7 X 6 X 3=126 | 4 X 4 X 3=48 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SON [Title/Abstract] AND XPC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SON | GO:0006397 | mRNA processing | 21504830 |
| Hgene | SON | GO:0043066 | negative regulation of apoptotic process | 10509013 |
| Hgene | SON | GO:0048024 | regulation of mRNA splicing, via spliceosome | 21504830 |
| Tgene | XPC | GO:0000715 | nucleotide-excision repair, DNA damage recognition | 10873465|19941824 |
| Tgene | XPC | GO:0006289 | nucleotide-excision repair | 8168482|9734359 |
| Tgene | XPC | GO:0070914 | UV-damage excision repair | 8077226 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AV736879 | SON | chr21 | 34915373 | - | XPC | chr3 | 14214540 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000356577 | ENST00000285021 | SON | chr21 | 34915373 | - | XPC | chr3 | 14214540 | - |
| 5UTR-3CDS | ENST00000356577 | ENST00000449060 | SON | chr21 | 34915373 | - | XPC | chr3 | 14214540 | - |
| 5UTR-3CDS | ENST00000290239 | ENST00000285021 | SON | chr21 | 34915373 | - | XPC | chr3 | 14214540 | - |
| 5UTR-3CDS | ENST00000290239 | ENST00000449060 | SON | chr21 | 34915373 | - | XPC | chr3 | 14214540 | - |
| 5UTR-3CDS | ENST00000381692 | ENST00000285021 | SON | chr21 | 34915373 | - | XPC | chr3 | 14214540 | - |
| 5UTR-3CDS | ENST00000381692 | ENST00000449060 | SON | chr21 | 34915373 | - | XPC | chr3 | 14214540 | - |
| intron-3CDS | ENST00000300278 | ENST00000285021 | SON | chr21 | 34915373 | - | XPC | chr3 | 14214540 | - |
| intron-3CDS | ENST00000300278 | ENST00000449060 | SON | chr21 | 34915373 | - | XPC | chr3 | 14214540 | - |
| intron-3CDS | ENST00000381679 | ENST00000285021 | SON | chr21 | 34915373 | - | XPC | chr3 | 14214540 | - |
| intron-3CDS | ENST00000381679 | ENST00000449060 | SON | chr21 | 34915373 | - | XPC | chr3 | 14214540 | - |
| intron-3CDS | ENST00000470533 | ENST00000285021 | SON | chr21 | 34915373 | - | XPC | chr3 | 14214540 | - |
| intron-3CDS | ENST00000470533 | ENST00000449060 | SON | chr21 | 34915373 | - | XPC | chr3 | 14214540 | - |
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FusionProtFeatures for SON_XPC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SON | XPC |