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Fusion gene ID: 35327 |
FusionGeneSummary for SNX6_ZC3H13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SNX6_ZC3H13 | Fusion gene ID: 35327 | Hgene | Tgene | Gene symbol | SNX6 | ZC3H13 | Gene ID | 58533 | 23091 |
| Gene name | sorting nexin 6 | zinc finger CCCH-type containing 13 | |
| Synonyms | MSTP010|TFAF2 | KIAA0853|Xio | |
| Cytomap | 14q13.1 | 13q14.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sorting nexin-6TRAF4-associated factor 2tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2 | zinc finger CCCH domain-containing protein 13 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9UNH7 | Q5T200 | |
| Ensembl transtripts involved in fusion gene | ENST00000396526, ENST00000396534, ENST00000362031, ENST00000355110, | ENST00000242848, ENST00000378921, ENST00000282007, ENST00000470308, | |
| Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 6 X 7 X 3=126 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SNX6 [Title/Abstract] AND ZC3H13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SNX6 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 11279102 |
| Hgene | SNX6 | GO:0045892 | negative regulation of transcription, DNA-templated | 11279102|20830743 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ028676 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000396526 | ENST00000242848 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-intron | ENST00000396526 | ENST00000378921 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-intron | ENST00000396526 | ENST00000282007 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-5UTR | ENST00000396526 | ENST00000470308 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-3CDS | ENST00000396534 | ENST00000242848 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-intron | ENST00000396534 | ENST00000378921 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-intron | ENST00000396534 | ENST00000282007 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-5UTR | ENST00000396534 | ENST00000470308 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-3CDS | ENST00000362031 | ENST00000242848 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-intron | ENST00000362031 | ENST00000378921 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-intron | ENST00000362031 | ENST00000282007 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-5UTR | ENST00000362031 | ENST00000470308 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-3CDS | ENST00000355110 | ENST00000242848 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-intron | ENST00000355110 | ENST00000378921 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-intron | ENST00000355110 | ENST00000282007 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
| intron-5UTR | ENST00000355110 | ENST00000470308 | SNX6 | chr14 | 35037953 | + | ZC3H13 | chr13 | 46577292 | + |
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FusionProtFeatures for SNX6_ZC3H13 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SNX6 | ZC3H13 |