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Fusion gene ID: 35282 |
FusionGeneSummary for SNX27_ILF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SNX27_ILF2 | Fusion gene ID: 35282 | Hgene | Tgene | Gene symbol | SNX27 | ILF2 | Gene ID | 81609 | 3608 |
| Gene name | sorting nexin family member 27 | interleukin enhancer binding factor 2 | |
| Synonyms | MRT1|MY014 | NF45|PRO3063 | |
| Cytomap | 1q21.3 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sorting nexin-27methamphetamine-responsive transcript 1 | interleukin enhancer-binding factor 2interleukin enhancer binding factor 2, 45kDinterleukin enhancer binding factor 2, 45kDanuclear factor of activated T-cells, 45-kDa | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q96L92 | Q12905 | |
| Ensembl transtripts involved in fusion gene | ENST00000458013, ENST00000368843, ENST00000368838, ENST00000482791, | ENST00000361891, ENST00000480213, ENST00000368681, | |
| Fusion gene scores | * DoF score | 11 X 6 X 9=594 | 5 X 5 X 2=50 |
| # samples | 11 | 6 | |
| ** MAII score | log2(11/594*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SNX27 [Title/Abstract] AND ILF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ILF2 | GO:0006351 | transcription, DNA-templated | 11739746 |
| Tgene | ILF2 | GO:0045893 | positive regulation of transcription, DNA-templated | 11739746 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-GN-A26A-06A | SNX27 | chr1 | 151665959 | + | ILF2 | chr1 | 153642706 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000458013 | ENST00000361891 | SNX27 | chr1 | 151665959 | + | ILF2 | chr1 | 153642706 | - |
| 5CDS-intron | ENST00000458013 | ENST00000480213 | SNX27 | chr1 | 151665959 | + | ILF2 | chr1 | 153642706 | - |
| 5CDS-intron | ENST00000458013 | ENST00000368681 | SNX27 | chr1 | 151665959 | + | ILF2 | chr1 | 153642706 | - |
| Frame-shift | ENST00000368843 | ENST00000361891 | SNX27 | chr1 | 151665959 | + | ILF2 | chr1 | 153642706 | - |
| 5CDS-intron | ENST00000368843 | ENST00000480213 | SNX27 | chr1 | 151665959 | + | ILF2 | chr1 | 153642706 | - |
| 5CDS-intron | ENST00000368843 | ENST00000368681 | SNX27 | chr1 | 151665959 | + | ILF2 | chr1 | 153642706 | - |
| Frame-shift | ENST00000368838 | ENST00000361891 | SNX27 | chr1 | 151665959 | + | ILF2 | chr1 | 153642706 | - |
| 5CDS-intron | ENST00000368838 | ENST00000480213 | SNX27 | chr1 | 151665959 | + | ILF2 | chr1 | 153642706 | - |
| 5CDS-intron | ENST00000368838 | ENST00000368681 | SNX27 | chr1 | 151665959 | + | ILF2 | chr1 | 153642706 | - |
| intron-3CDS | ENST00000482791 | ENST00000361891 | SNX27 | chr1 | 151665959 | + | ILF2 | chr1 | 153642706 | - |
| intron-intron | ENST00000482791 | ENST00000480213 | SNX27 | chr1 | 151665959 | + | ILF2 | chr1 | 153642706 | - |
| intron-intron | ENST00000482791 | ENST00000368681 | SNX27 | chr1 | 151665959 | + | ILF2 | chr1 | 153642706 | - |
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FusionProtFeatures for SNX27_ILF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SNX27 | ILF2 |