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Fusion gene ID: 35179 |
FusionGeneSummary for SNRNP48_STK3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SNRNP48_STK3 | Fusion gene ID: 35179 | Hgene | Tgene | Gene symbol | SNRNP48 | STK3 | Gene ID | 154007 | 8428 |
| Gene name | small nuclear ribonucleoprotein U11/U12 subunit 48 | serine/threonine kinase 24 | |
| Synonyms | C6orf151|dJ336K20B.1|dJ512B11.2 | HEL-S-95|MST3|MST3B|STE20|STK3 | |
| Cytomap | 6p24.3 | 13q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | U11/U12 small nuclear ribonucleoprotein 48 kDa proteinU11-48KU11/U12 snRNP 48 kDa proteinU11/U12 snRNP 48KU11/U12-48Ksmall nuclear ribonucleoprotein 48kDa (U11/U12)small nuclear ribonucleoprotein, U11/U12 48KDa subunit | serine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6IEG0 | Q13188 | |
| Ensembl transtripts involved in fusion gene | ENST00000342415, | ENST00000419617, ENST00000523601, ENST00000521768, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 6 X 5 X 4=120 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SNRNP48 [Title/Abstract] AND STK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STK3 | GO:0006468 | protein phosphorylation | 19604147 |
| Tgene | STK3 | GO:0042542 | response to hydrogen peroxide | 22291017 |
| Tgene | STK3 | GO:0046777 | protein autophosphorylation | 17046825|17657516 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-GM-A2DD-01A | SNRNP48 | chr6 | 7594392 | + | STK3 | chr8 | 99896062 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000342415 | ENST00000419617 | SNRNP48 | chr6 | 7594392 | + | STK3 | chr8 | 99896062 | - |
| 5CDS-5UTR | ENST00000342415 | ENST00000523601 | SNRNP48 | chr6 | 7594392 | + | STK3 | chr8 | 99896062 | - |
| 5CDS-intron | ENST00000342415 | ENST00000521768 | SNRNP48 | chr6 | 7594392 | + | STK3 | chr8 | 99896062 | - |
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FusionProtFeatures for SNRNP48_STK3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SNRNP48 | STK3 |