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Fusion gene ID: 35144 |
FusionGeneSummary for SNHG5_HEY1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SNHG5_HEY1 | Fusion gene ID: 35144 | Hgene | Tgene | Gene symbol | SNHG5 | HEY1 | Gene ID | 387066 | 23462 |
| Gene name | small nucleolar RNA host gene 5 | hes related family bHLH transcription factor with YRPW motif 1 | |
| Synonyms | C6orf160|LINC00044|NCRNA00044|U50HG | BHLHb31|CHF2|HERP2|HESR1|HRT-1|OAF1|hHRT1 | |
| Cytomap | 6q14.3 | 8q21.13 | |
| Type of gene | ncRNA | protein-coding | |
| Description | U50 hostlong intergenic non-protein coding RNA 44small nucleolar RNA host gene 5 (non-protein coding) | hairy/enhancer-of-split related with YRPW motif protein 1HES-related repressor protein 1HES-related repressor protein 2basic helix-loop-helix protein OAF1cardiovascular helix-loop-helix factor 2class B basic helix-loop-helix protein 31hairy and enha | |
| Modification date | 20180422 | 20180523 | |
| UniProtAcc | Q9Y5J3 | ||
| Ensembl transtripts involved in fusion gene | ENST00000384338, ENST00000364995, | ENST00000354724, ENST00000337919, ENST00000435063, ENST00000523976, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SNHG5 [Title/Abstract] AND HEY1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HEY1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16043483|21290414 |
| Tgene | HEY1 | GO:0007219 | Notch signaling pathway | 10964718|25985737 |
| Tgene | HEY1 | GO:0045746 | negative regulation of Notch signaling pathway | 18239137 |
| Tgene | HEY1 | GO:0045892 | negative regulation of transcription, DNA-templated | 15485867 |
| Tgene | HEY1 | GO:2000678 | negative regulation of transcription regulatory region DNA binding | 18239137 |
| Tgene | HEY1 | GO:2000820 | negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation | 18239137 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA946891 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000384338 | ENST00000354724 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| intron-5UTR | ENST00000384338 | ENST00000337919 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| intron-intron | ENST00000384338 | ENST00000435063 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| intron-intron | ENST00000384338 | ENST00000523976 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| 5CDS-5UTR | ENST00000364995 | ENST00000354724 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| 5CDS-5UTR | ENST00000364995 | ENST00000337919 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| 5CDS-intron | ENST00000364995 | ENST00000435063 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
| 5CDS-intron | ENST00000364995 | ENST00000523976 | SNHG5 | chr6 | 86387308 | - | HEY1 | chr8 | 80680002 | - |
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FusionProtFeatures for SNHG5_HEY1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SNHG5 | HEY1 |