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Fusion gene ID: 35129

FusionGeneSummary for SNHG3_AIFM1

Fusion gene summary

Fusion gene information	Fusion gene name: SNHG3_AIFM1
	Fusion gene ID: 35129
		Hgene	Tgene
	Gene symbol	SNHG3	AIFM1
	Gene ID	8420	9131
	Gene name	small nucleolar RNA host gene 3	apoptosis inducing factor mitochondria associated 1
	Synonyms	NCRNA00014\|RNU17C\|RNU17D\|U17HG\|U17HG-A\|U17HG-AB	AIF\|CMT2D\|CMTX4\|COWCK\|COXPD6\|DFNX5\|NADMR\|NAMSD\|PDCD8
	Cytomap	1p35.3	Xq26.1
	Type of gene	ncRNA	protein-coding
	Description	U17 small nucleolar RNA hostsmall nucleolar RNA host gene (non-protein coding) 3small nucleolar RNA host gene 3 (non-protein coding)	apoptosis-inducing factor 1, mitochondrialapoptosis-inducing factor, mitochondrion-associated, 1programmed cell death 8 (apoptosis-inducing factor)striatal apoptosis-inducing factortesticular secretory protein Li 4
	Modification date	20180519	20180527
	UniProtAcc		O95831
	Ensembl transtripts involved in fusion gene	ENST00000364938,	ENST00000460436, ENST00000440263, ENST00000535724, ENST00000346424, ENST00000319908, ENST00000287295,
Fusion gene scores	* DoF score	15 X 7 X 4=420	2 X 2 X 1=4
	# samples	15	2
	** MAII score	log2(15/420*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: SNHG3 [Title/Abstract] AND AIFM1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	AIFM1	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	17094969

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BG108121	SNHG3	chr1	28835429	+	AIFM1	chrX	129265777	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000364938	ENST00000460436	SNHG3	chr1	28835429	+	AIFM1	chrX	129265777	-
intron-3CDS	ENST00000364938	ENST00000440263	SNHG3	chr1	28835429	+	AIFM1	chrX	129265777	-
intron-3UTR	ENST00000364938	ENST00000535724	SNHG3	chr1	28835429	+	AIFM1	chrX	129265777	-
intron-3UTR	ENST00000364938	ENST00000346424	SNHG3	chr1	28835429	+	AIFM1	chrX	129265777	-
intron-3UTR	ENST00000364938	ENST00000319908	SNHG3	chr1	28835429	+	AIFM1	chrX	129265777	-
intron-3UTR	ENST00000364938	ENST00000287295	SNHG3	chr1	28835429	+	AIFM1	chrX	129265777	-

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FusionProtFeatures for SNHG3_AIFM1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SNHG3	AIFM1 O95831

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Fusion gene ID: 35129

FusionGeneSummary for SNHG3_AIFM1

FusionProtFeatures for SNHG3_AIFM1