|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 35093 |
FusionGeneSummary for SND1_SPTBN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SND1_SPTBN1 | Fusion gene ID: 35093 | Hgene | Tgene | Gene symbol | SND1 | SPTBN1 | Gene ID | 27044 | 6711 |
| Gene name | staphylococcal nuclease and tudor domain containing 1 | spectrin beta, non-erythrocytic 1 | |
| Synonyms | TDRD11|Tudor-SN|p100 | ELF|HEL102|SPTB2|betaSpII | |
| Cytomap | 7q32.1 | 2p16.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | staphylococcal nuclease domain-containing protein 1EBNA2 coactivator p100testis tissue sperm-binding protein Li 82Ptudor domain-containing protein 11 | spectrin beta chain, non-erythrocytic 1beta-G spectrinbeta-II spectrinbeta-fodrinbeta-spectrin 2beta-spectrin IIbeta-spectrin non-erythrocytic 1embryonic liver beta-fodrinepididymis luminal protein 102fodrin beta chainspectrin beta chain, brain | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q7KZF4 | Q01082 | |
| Ensembl transtripts involved in fusion gene | ENST00000354725, ENST00000467238, | ENST00000356805, ENST00000333896, | |
| Fusion gene scores | * DoF score | 13 X 14 X 7=1274 | 13 X 13 X 6=1014 |
| # samples | 20 | 15 | |
| ** MAII score | log2(20/1274*10)=-2.67129337248158 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/1014*10)=-2.75702324650746 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SND1 [Title/Abstract] AND SPTBN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF081959 | SND1 | chr7 | 127724896 | + | SPTBN1 | chr2 | 54886326 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000354725 | ENST00000356805 | SND1 | chr7 | 127724896 | + | SPTBN1 | chr2 | 54886326 | + |
| Frame-shift | ENST00000354725 | ENST00000333896 | SND1 | chr7 | 127724896 | + | SPTBN1 | chr2 | 54886326 | + |
| intron-3CDS | ENST00000467238 | ENST00000356805 | SND1 | chr7 | 127724896 | + | SPTBN1 | chr2 | 54886326 | + |
| intron-3CDS | ENST00000467238 | ENST00000333896 | SND1 | chr7 | 127724896 | + | SPTBN1 | chr2 | 54886326 | + |
Top |
FusionProtFeatures for SND1_SPTBN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SND1 | SPTBN1 |