|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 35085 |
FusionGeneSummary for SND1_GRM8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SND1_GRM8 | Fusion gene ID: 35085 | Hgene | Tgene | Gene symbol | SND1 | GRM8 | Gene ID | 27044 | 2918 |
| Gene name | staphylococcal nuclease and tudor domain containing 1 | glutamate metabotropic receptor 8 | |
| Synonyms | TDRD11|Tudor-SN|p100 | GLUR8|GPRC1H|MGLUR8|mGlu8 | |
| Cytomap | 7q32.1 | 7q31.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | staphylococcal nuclease domain-containing protein 1EBNA2 coactivator p100testis tissue sperm-binding protein Li 82Ptudor domain-containing protein 11 | metabotropic glutamate receptor 8glutamate receptor, metabotropic 8 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7KZF4 | O00222 | |
| Ensembl transtripts involved in fusion gene | ENST00000354725, ENST00000467238, | ENST00000444921, ENST00000339582, ENST00000358373, ENST00000405249, ENST00000480995, | |
| Fusion gene scores | * DoF score | 13 X 14 X 7=1274 | 7 X 7 X 6=294 |
| # samples | 20 | 8 | |
| ** MAII score | log2(20/1274*10)=-2.67129337248158 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/294*10)=-1.877744249949 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SND1 [Title/Abstract] AND GRM8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GRM8 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | 11166323 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A1-A0SN-01A | SND1 | chr7 | 127361454 | + | GRM8 | chr7 | 126544737 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000354725 | ENST00000444921 | SND1 | chr7 | 127361454 | + | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000354725 | ENST00000339582 | SND1 | chr7 | 127361454 | + | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000354725 | ENST00000358373 | SND1 | chr7 | 127361454 | + | GRM8 | chr7 | 126544737 | - |
| Frame-shift | ENST00000354725 | ENST00000405249 | SND1 | chr7 | 127361454 | + | GRM8 | chr7 | 126544737 | - |
| 5CDS-5UTR | ENST00000354725 | ENST00000480995 | SND1 | chr7 | 127361454 | + | GRM8 | chr7 | 126544737 | - |
| intron-3CDS | ENST00000467238 | ENST00000444921 | SND1 | chr7 | 127361454 | + | GRM8 | chr7 | 126544737 | - |
| intron-3CDS | ENST00000467238 | ENST00000339582 | SND1 | chr7 | 127361454 | + | GRM8 | chr7 | 126544737 | - |
| intron-3CDS | ENST00000467238 | ENST00000358373 | SND1 | chr7 | 127361454 | + | GRM8 | chr7 | 126544737 | - |
| intron-3CDS | ENST00000467238 | ENST00000405249 | SND1 | chr7 | 127361454 | + | GRM8 | chr7 | 126544737 | - |
| intron-5UTR | ENST00000467238 | ENST00000480995 | SND1 | chr7 | 127361454 | + | GRM8 | chr7 | 126544737 | - |
Top |
FusionProtFeatures for SND1_GRM8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SND1 | GRM8 |