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Fusion gene ID: 35038

FusionGeneSummary for SMYD3_ZNF695

Fusion gene summary

Fusion gene information	Fusion gene name: SMYD3_ZNF695
	Fusion gene ID: 35038
		Hgene	Tgene
	Gene symbol	SMYD3	ZNF695
	Gene ID	64754	57116
	Gene name	SET and MYND domain containing 3	zinc finger protein 695
	Synonyms	KMT3E\|ZMYND1\|ZNFN3A1\|bA74P14.1	SBZF3
	Cytomap	1q44	1q44
	Type of gene	protein-coding	protein-coding
	Description	histone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1	zinc finger protein 695zinc finger protein SBZF3
	Modification date	20180519	20180519
	UniProtAcc	Q9H7B4	Q8IW36
	Ensembl transtripts involved in fusion gene	ENST00000541742, ENST00000490107, ENST00000388985, ENST00000366517, ENST00000403792,	ENST00000487338, ENST00000498046, ENST00000339986,
Fusion gene scores	* DoF score	10 X 7 X 9=630	2 X 2 X 4=16
	# samples	12	4
	** MAII score	log2(12/630*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SMYD3 [Title/Abstract] AND ZNF695 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BLCA	TCGA-DK-AA6W-01A	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
TCGA	RV	ESCA	TCGA-LN-A4A1-01A	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
TCGA	RV	HNSC	TCGA-CN-6018-01A	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000541742	ENST00000487338	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
intron-5UTR	ENST00000541742	ENST00000498046	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
intron-intron	ENST00000541742	ENST00000339986	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
5UTR-3CDS	ENST00000490107	ENST00000487338	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
5UTR-5UTR	ENST00000490107	ENST00000498046	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
5UTR-intron	ENST00000490107	ENST00000339986	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
Frame-shift	ENST00000388985	ENST00000487338	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
5CDS-5UTR	ENST00000388985	ENST00000498046	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
5CDS-intron	ENST00000388985	ENST00000339986	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
intron-3CDS	ENST00000366517	ENST00000487338	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
intron-5UTR	ENST00000366517	ENST00000498046	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
intron-intron	ENST00000366517	ENST00000339986	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
Frame-shift	ENST00000403792	ENST00000487338	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
5CDS-5UTR	ENST00000403792	ENST00000498046	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
5CDS-intron	ENST00000403792	ENST00000339986	SMYD3	chr1	246670356	-	ZNF695	chr1	247109129	-
intron-3CDS	ENST00000541742	ENST00000487338	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
intron-5UTR	ENST00000541742	ENST00000498046	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
intron-intron	ENST00000541742	ENST00000339986	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
5UTR-3CDS	ENST00000490107	ENST00000487338	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
5UTR-5UTR	ENST00000490107	ENST00000498046	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
5UTR-intron	ENST00000490107	ENST00000339986	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
In-frame	ENST00000388985	ENST00000487338	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
5CDS-5UTR	ENST00000388985	ENST00000498046	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
5CDS-intron	ENST00000388985	ENST00000339986	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
intron-3CDS	ENST00000366517	ENST00000487338	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
intron-5UTR	ENST00000366517	ENST00000498046	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
intron-intron	ENST00000366517	ENST00000339986	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
In-frame	ENST00000403792	ENST00000487338	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
5CDS-5UTR	ENST00000403792	ENST00000498046	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-
5CDS-intron	ENST00000403792	ENST00000339986	SMYD3	chr1	246670356	-	ZNF695	chr1	247131094	-

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FusionProtFeatures for SMYD3_ZNF695

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SMYD3 Q9H7B4	ZNF695 Q8IW36

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Fusion gene ID: 35038

FusionGeneSummary for SMYD3_ZNF695

FusionProtFeatures for SMYD3_ZNF695