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Fusion gene ID: 35036

FusionGeneSummary for SMYD3_WLS

Fusion gene summary

Fusion gene information	Fusion gene name: SMYD3_WLS
	Fusion gene ID: 35036
		Hgene	Tgene
	Gene symbol	SMYD3	WLS
	Gene ID	64754	79971
	Gene name	SET and MYND domain containing 3	wntless Wnt ligand secretion mediator
	Synonyms	KMT3E\|ZMYND1\|ZNFN3A1\|bA74P14.1	C1orf139\|EVI\|GPR177\|MRP\|mig-14
	Cytomap	1q44	1p31.3
	Type of gene	protein-coding	protein-coding
	Description	histone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1	protein wntless homologG protein-coupled receptor 177integral membrane protein GPR177protein evenness interrupted homologputative NF-kappa-B-activating protein 373putative NFkB activating protein 373
	Modification date	20180519	20180527
	UniProtAcc	Q9H7B4	Q5T9L3
	Ensembl transtripts involved in fusion gene	ENST00000541742, ENST00000490107, ENST00000388985, ENST00000366517, ENST00000403792,	ENST00000540432, ENST00000354777, ENST00000262348, ENST00000370976, ENST00000370971, ENST00000491811,
Fusion gene scores	* DoF score	10 X 7 X 9=630	4 X 2 X 4=32
	# samples	12	4
	** MAII score	log2(12/630*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SMYD3 [Title/Abstract] AND WLS [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BRCA	TCGA-E9-A1N6-01A	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000541742	ENST00000540432	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
In-frame	ENST00000541742	ENST00000354777	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
In-frame	ENST00000541742	ENST00000262348	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
5CDS-intron	ENST00000541742	ENST00000370976	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
5CDS-intron	ENST00000541742	ENST00000370971	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
5CDS-intron	ENST00000541742	ENST00000491811	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
Frame-shift	ENST00000490107	ENST00000540432	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
Frame-shift	ENST00000490107	ENST00000354777	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
Frame-shift	ENST00000490107	ENST00000262348	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
5CDS-intron	ENST00000490107	ENST00000370976	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
5CDS-intron	ENST00000490107	ENST00000370971	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
5CDS-intron	ENST00000490107	ENST00000491811	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
Frame-shift	ENST00000388985	ENST00000540432	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
Frame-shift	ENST00000388985	ENST00000354777	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
Frame-shift	ENST00000388985	ENST00000262348	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
5CDS-intron	ENST00000388985	ENST00000370976	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
5CDS-intron	ENST00000388985	ENST00000370971	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
5CDS-intron	ENST00000388985	ENST00000491811	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
intron-3CDS	ENST00000366517	ENST00000540432	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
intron-3CDS	ENST00000366517	ENST00000354777	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
intron-3CDS	ENST00000366517	ENST00000262348	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
intron-intron	ENST00000366517	ENST00000370976	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
intron-intron	ENST00000366517	ENST00000370971	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
intron-intron	ENST00000366517	ENST00000491811	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
Frame-shift	ENST00000403792	ENST00000540432	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
Frame-shift	ENST00000403792	ENST00000354777	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
Frame-shift	ENST00000403792	ENST00000262348	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
5CDS-intron	ENST00000403792	ENST00000370976	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
5CDS-intron	ENST00000403792	ENST00000370971	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-
5CDS-intron	ENST00000403792	ENST00000491811	SMYD3	chr1	246518333	-	WLS	chr1	68659910	-

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FusionProtFeatures for SMYD3_WLS

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SMYD3 Q9H7B4	WLS Q5T9L3

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Fusion gene ID: 35036

FusionGeneSummary for SMYD3_WLS

FusionProtFeatures for SMYD3_WLS