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Fusion gene ID: 35035 |
FusionGeneSummary for SMYD3_TRIM58 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMYD3_TRIM58 | Fusion gene ID: 35035 | Hgene | Tgene | Gene symbol | SMYD3 | TRIM58 | Gene ID | 64754 | 25893 |
| Gene name | SET and MYND domain containing 3 | tripartite motif containing 58 | |
| Synonyms | KMT3E|ZMYND1|ZNFN3A1|bA74P14.1 | BIA2 | |
| Cytomap | 1q44 | 1q44 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1 | E3 ubiquitin-protein ligase TRIM58RING-type E3 ubiquitin transferase TRIM58tripartite motif-containing protein 58 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9H7B4 | Q8NG06 | |
| Ensembl transtripts involved in fusion gene | ENST00000541742, ENST00000490107, ENST00000388985, ENST00000366517, ENST00000403792, | ENST00000366481, | |
| Fusion gene scores | * DoF score | 10 X 7 X 9=630 | 4 X 3 X 3=36 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/630*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SMYD3 [Title/Abstract] AND TRIM58 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-7789-01A | SMYD3 | chr1 | 246490503 | - | TRIM58 | chr1 | 248023919 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000541742 | ENST00000366481 | SMYD3 | chr1 | 246490503 | - | TRIM58 | chr1 | 248023919 | + |
| In-frame | ENST00000490107 | ENST00000366481 | SMYD3 | chr1 | 246490503 | - | TRIM58 | chr1 | 248023919 | + |
| In-frame | ENST00000388985 | ENST00000366481 | SMYD3 | chr1 | 246490503 | - | TRIM58 | chr1 | 248023919 | + |
| intron-3CDS | ENST00000366517 | ENST00000366481 | SMYD3 | chr1 | 246490503 | - | TRIM58 | chr1 | 248023919 | + |
| In-frame | ENST00000403792 | ENST00000366481 | SMYD3 | chr1 | 246490503 | - | TRIM58 | chr1 | 248023919 | + |
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FusionProtFeatures for SMYD3_TRIM58 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMYD3 | TRIM58 |